The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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pathophysiology gh growthhormone lower signs symptoms urinarytractinfection 21ohd complications diagnosis feedbackloop genetics hyperthyroidism overproduction pediatrics peds pituitary primary
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
Growth Hormone Excess ... of onset of GH excess ... GH excess prior ... GH excess after ... signs #symptoms #endocrinology
Primary Hyperthyroidism - Pathogenesis and Clinical Findings Note: Although rare, gestational diseases can lead to thyrotoxicosis due
thyrotoxicosis due to excess ... hyperthyroidism due to excess ... Hyperthyroidism #endocrinology
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
a scrotum #21HydroxylaseDeficiency ... pathophysiology #genetics #endocrinology
Lower Urinary Tract Infection: Pathogenesis and Clinical Findings - Predisposing Factors: Immunocompromised state, diabetes, elderly, female
Fecal bacteria access ... Incr WBC (Rare in LUTI ... UrinaryTractInfection #LUTI
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
lipid • GH excess ... #FeedbackLoop #endocrinology
Lower Urinary Tract Infections: Complications - Infection damages the urinary tract epithelium causing fibroblast proliferation and
Bacteria gain access ... UrinaryTractInfection #LUTI
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