The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Graves’ Disease: Pathogenesis and Clinical Findings
B & T lymphocyte mediated autoimmunity attack TSH receptor -> Continuous
GravesDisease #pathophysiology ... #endocin #endocrinology
Meralgia paresthetica: Pathogenesis and Clinical Findings
Compression/injury of Lateral Femoral Cutaneous Nerve (LFCN) -> Meralgia paresthetica
 •
Tingling, Burning, Stinging ... , Stabbing) - ... MeralgiaParesthetica #MSK ... #pathophysiology
Disc Herniations - Pathogenesis and Complications
• 90% of Lumbar disc herniations happen at L4/5 and L5/S1
•
happen at C6/7 Aging ... complications #msk ... #pathophysiology
Radiculopathy: Signs and Symptoms
 • Back/Neck Pain
 • Decr Range of motion
 • Abnormal posturing
 •
: -> Shooting, stabbing ... Radiculopathy #MSK ... signs #symptoms #pathophysiology
Cauda Equina Syndrome
Causes:
 • Large lumbar degenerative disc herniation (central)
 • Severe lumbar spondylosis
 • Neoplasm
pain (shooting, stabbing ... CaudaEquina #Syndrome #MSK ... #pathophysiology
Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings

 • Primary (Idiopathic): Unknown etiology, but associated
FrozenShoulder #pathophysiology ... signs #stages #staging ... #msk
Menstrual Cycle Physiology: Correlating the Ovarian and Uterine Cycles
Note: Some charts show different relative levels of
#OvarianCycle #pathophysiology ... #comparison #endocrinology
Distinguishing between Inflammatory and Degenerative joint disease
Inflammatory Joint Disease
 • Swelling stimulates joint nociceptors -> Pain
#Degenerative #Comparison ... #Versus #MSK #JointDisease ... JointPain #Diagnosis #pathophysiology
Dupuytren’s Disease: Pathogenesis and Clinical Findings
 • Aging, smoking and/or diabetes -> Microangiopathy and palmar fascia
Clinical Findings • Aging ... #Contractures #pathophysiology ... #msk
Fracture Healing (and disruptors of this process)
Inflammatory Stage (0-7d)
 • Fracture disrupts local blood vessels ->
- Metabolic / Endocrine ... #Orthopedics #msk ... #Staging #pathophysiology