The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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pathophysiology diagnosis genetics growthhormone peds pituitary 21hydroxylasedeficiency 21ohd diabeticketoacidosis dka dysfunction erectile excess fecal feedbackloop geriatrics glftap incontinence macroadenoma masseffects
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Growth Hormone (GH ... /Symptoms: • GH ... abn lipid • GH ... GrowthHormone #GH ... #FeedbackLoop #endocrinology
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
time of onset of GH ... GH excess prior ... GH excess after ... GrowthHormone #GH ... signs #symptoms #endocrinology
Pituitary Mass Effects - Pathogenesis and Clinical Findings • Pituitary turnors are almost always a benign
following order; GH ... Hyperprolactinemia • Diabetes ... #SideEffects #endocrinology
Erectile Dysfunction: Pathogenesis Erectile Dysfunction - Persistent or recurrent inability to achieve an erection sufficient to achieve
trauma, iatrogenic, diabetes ... and rigidity Endocrinologic ... hyperlipidemia, diabetes ... (penile artery diameter
Prader-Willi Syndrome: Pathogenesis and clinical findings • Maternal uniparental disomy: inheriting 2 copies of maternal chromosome
Obesity -> Type 2 diabetes ... pathophysiology #peds #pediatrics
Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings • Note: in DKA, body K+ is lost
Diabetic Ketoacidosis ... pathophysiology #endocrinology ... #diabetes
Fecal Incontinence - Pathogenesis and Complications Continence mechanisms are impaired • Local neuronal damage • External and
Diabetes) • Altered ... #Incontinence #geriatrics
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
pathophysiology #genetics #endocrinology ... #peds #pediatrics
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