The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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pathophysiology growthhormone radiology xray antipsychotics benign diabetes diabeticketoacidosis excess features feedbackloop malignant mechanisms overproduction pharmacology pituitary psychiatry secondgeneration sideeffects signs
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Growth Hormone (GH ... Incr IGF1 • Bone ... /Symptoms: • GH ... abn lipid • GH ... #FeedbackLoop #endocrinology
Malignant Bone Tumors: Pathogenesis of X-ray appearance • Metastatic bone tumors (aka. cancerous cells from systemic
Malignant Bone Tumors ... • Metastatic bone ... tumors (aka. cancerous ... tumor #BoneTumors ... Malignant #Radiology #Diagnosis
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
time of onset of GH ... GH excess prior ... GH excess after ... Overproduction #diagnosis ... signs #symptoms #endocrinology
Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings • Note: in DKA, body K+ is lost
Ketoacidosis (DKA ... Findings • Note: in DKA ... , body K+ is lost ... brain... thus, the body ... pathophysiology #endocrinology
Benign Primary Bone Tumors: Pathogenesis of X-ray appearance • "Geographic" bone destruction • Lack of soft-tissue
Benign Primary Bone ... • "Geographic" bone ... periosteum) #Benign #BoneTumors ... #XRay #diagnosis
Second Generation Antipsychotics: Mechanisms and Side Effects (Atypical Anti-Psychotics) - Examples: Clozapine, Olanzapine, Quetiapine, Risperidone, Zotepine, Paliperidone,
Block action of DA ... action throughout body ... action throughout body ... #pharmacology #diagnosis
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