The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Malignant Bone Tumors: Clinical Findings and Complications

#Malignant #BoneTumors #Bony #Complications #pathophysiology
Malignant Bone Tumors ... #Malignant #BoneTumors ... #Bony #Complications ... #pathophysiology
Representative X-ray appearance of a primary malignant bone tumor - Ewings Sarcoma
 • "Interrupted periosteal reaction
primary malignant bone ... Moth-eaten", permeative bone ... transition between bone ... Radiology #Clinical #Labeled ... LegXRay #Malignant #BoneTumor
Representative X-ray appearance of a primary benign bone tumor - Aneurysmal Bone Cyst 
 • Soft
primary benign bone ... tumor - Aneurysmal Bone ... Narrowing • Bony ... Radiology #Clinical #Labeled ... #Benign #BoneTumor
Malignant Bone Tumors: Pathogenesis of X-ray appearance

 • Metastatic bone tumors (aka. cancerous cells from systemic
Malignant Bone Tumors ... • Metastatic bone ... tumors (aka. cancerous ... • Metastatic bone ... tumor #BoneTumors
Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings
 • Note: in DKA, body K+ is lost
Ketoacidosis (DKA ... , body K+ is lost ... brain... thus, the body ... #pathophysiology ... #endocrinology
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Incr IGF1 • Bone ... #FeedbackLoop #endocrinology ... #pathophysiology
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings
Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
Females may be labeled ... #21HydroxylaseDeficiency #21OHD #pathophysiology ... #genetics #endocrinology
Bulimia Nervosa: Pathogenesis and Risk Factors
Biological Risk Factors
 • Gender: F > M
 • Genetics: Some
of ideal female body ... and very little body ... Childhood obesity (body ... Dysregulation - Labile ... BulimiaNervosa #pathophysiology