The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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pathophysiology diagnosis gh growthhormone pituitary antipsychotics diabetes diabeticketoacidosis feedbackloop glftap hyperthyroidism macroadenoma masseffects mechanisms mnemonic overproduction pharmacology primary psychiatry symptoms
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
Growth Hormone Excess ... GH excess prior ... GH excess after ... Overproduction #diagnosis #signs ... #symptoms #endocrinology
Primary Hyperthyroidism - Pathogenesis and Clinical Findings Note: Although rare, gestational diseases can lead to thyrotoxicosis due
thyrotoxicosis due to excess ... hyperthyroidism due to excess ... Signs/Symptoms: ... Hyperthyroidism #endocrinology
Third Generation Antipsychotics: Mechanisms and Side Effects (Atypical Anti-Psychotics) Example: Aripiprazole Dopamine D2 Receptor Partial Agonist • Binds
• Prevents excess ... DA from over-stimulating ... and deficient DA ... does not allow excess ... ThirdGeneration #Mechanisms #SideEffects
Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings • Note: in DKA, body K+ is lost
Ketoacidosis (DKA ... Findings • Note: in DKA ... Treating DKA: 1) ... Signs/Symptoms/Complications ... pathophysiology #endocrinology
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
activates lipolysis Signs ... lipid • GH excess ... #FeedbackLoop #endocrinology
Pituitary Mass Effects - Pathogenesis and Clinical Findings • Pituitary turnors are almost always a benign
Signs / Symptoms ... #Macroadenoma #SideEffects ... #endocrinology
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