The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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pathophysiology diagnosis symptoms genetics msk pediatrics peds sideeffects 21hydroxylasedeficiency 21ohd acute alzheimersdisease arteritis caudaequina dementia excess gh glftap growthhormone inhibitors
Alzheimer’s Disease: Pathogenesis and Clinical Findings Risk factor for Late Onset Alzheimer's (99% of cases): - Increasing
mutations - Down syndrome ... chromosome 21) Signs ... Executive planning dysfunction ... pathophysiology #geriatrics ... #diagnosis #signs
Acute Spinal Cord Injuries: Pathogenesis and clinical findings • Anterior Cord Syndrome -> Anterior spinal artery
Anterior Cord Syndrome ... • Central Cord Syndrome ... Upper Extremity Dysfunction ... deficiencies -> Sphincter dysfunction ... pathophysiology #signs
Serotonin-Norepinephrine Reuptake Inhibitors(SNRIs): Mechanisms and Side Effects Withdrawal: Dizziness, Diarrhea, Insomnia, Nausea, Vomiting Serotonin Syndrome - Potentially Life
Vomiting Serotonin Syndrome ... Vertigo, Sexual Dysfunction ... Psychiatry #Diagnosis #Signs
Cauda Equina Syndrome Causes: • Large lumbar degenerative disc herniation (central) • Severe lumbar spondylosis • Neoplasm
Cauda Equina Syndrome ... lumbar spine Signs ... bladder/bowel dysfunction ... #CaudaEquina #Syndrome ... diagnosis #symptoms #signs
Prader-Willi Syndrome: Pathogenesis and clinical findings • Maternal uniparental disomy: inheriting 2 copies of maternal chromosome
Prader-Willi Syndrome ... =>Prader-Willi Syndrome ... Signs/Symptoms ... #PraderWilli #Syndrome ... pathophysiology #peds #pediatrics
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
Carpal Tunnel Syndrome ... Overproduction #diagnosis #signs ... #symptoms #endocrinology
Pituitary Mass Effects - Pathogenesis and Clinical Findings • Pituitary turnors are almost always a benign
Signs / Symptoms ... • Hypothalamic dysfunction ... #SideEffects #endocrinology
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
Signs/Symptoms/Complications ... pathophysiology #genetics #endocrinology ... #peds #pediatrics
Takayasu’s Arteritis: Pathogenesis and clinical findings - Fatigue, weight loss, low grade fever, arthralgias - Incr
aneurysms - Visual Dysfunction ... Acute Coronary Syndrome ... Vasculitis #Diagnosis #Signs
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