The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
activates lipolysis Signs ... /Symptoms: • GH ... lipid • GH excess ... GrowthHormone #GH #FeedbackLoop ... #endocrinology
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
Growth Hormone Excess ... GH excess prior ... GH excess after ... Overproduction #diagnosis #signs ... #symptoms #endocrinology
Primary Hyperthyroidism - Pathogenesis and Clinical Findings

Note: Although rare, gestational diseases can lead to thyrotoxicosis due
thyrotoxicosis due to excess ... hyperthyroidism due to excess ... Signs/Symptoms: ... Hyperthyroidism #endocrinology
Borderline Personality Disorder: Pathogenesis and Clinical Findings
Behavioral Traits:
 • Unstable Relationships - Alternating extremes of idealization
experienced BPD Mnemonic ... the above with symptoms ... BPD #Borderline #PersonalityDisorder ... Psychiatry #Criteria #Signs ... #Symptoms #Mnemonic
Schizotypal Personality Disorder (SPD): Pathogenesis and clinical findings
Cognitive-Perceptual
 • Magical thinking - Belief in paranormal or
familiarity SPD Mnemonic ... #Schizotypal #PersonalityDisorder ... Psychiatry #Criteria #Signs ... #Symptoms #Mnemonic
Dependent Personality Disorder (DPD): Pathogenesis and Clinical Findings
 • Difficulties with Activities - Initiation Of projects
themselves DPD Mnemonic ... DPD #Dependent #PersonalityDisorder ... Psychiatry #Criteria #Signs ... #Symptoms #Mnemonic
Pituitary Mass Effects - Pathogenesis and Clinical Findings
 • Pituitary turnors are almost always a benign
A good mnemonic ... Signs / Symptoms ... #SideEffects #endocrinology ... #mnemonic #GLFTAP
Avoidant Personality Disorder (AVPD): Pathogenesis and Clinical Findings
 • Restraint - Shows excessive restraint in intimate
others AVPD Mnemonic ... AVPD #Avoidant #PersonalityDisorder ... Psychiatry #Criteria #Signs ... #Symptoms #Mnemonic
Narcissistic Personality Disorder: Pathogenesis and Clinical Findings
 • Arrogant, Haughty Behaviors or Attitude - Often display
of others NPD Mnemonic ... - Entitlement, Excess ... #Narcissistic #PersonalityDisorder ... Psychiatry #Criteria #Signs ... #Symptoms #Mnemonic
Antisocial Personality Disorder (ASPD): Pathogenesis and Clinical Findings
Work & lnterpersonal:
 • Home Life Troubles - Conflict
assault ASPD Mnemonic ... ASPD #Antisocial #PersonalityDisorder ... Psychiatry #Criteria #Signs ... #Symptoms #Mnemonic