The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Central Retinal Vein Occlusion (CRVO): Pathogenesis and clinical findings

#CentralRetinalVein #Occlusion #CRVO #pathophysiology #ophthalmology #diagnosis #signs #symptoms
Central Retinal Vein Occlusion ... CentralRetinalVein #Occlusion ... pathophysiology #ophthalmology ... #diagnosis #signs
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Growth Hormone (GH ... activates lipolysis Signs ... /Symptoms: • GH ... abn lipid • GH ... #FeedbackLoop #endocrinology
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
GH excess prior ... GH excess after ... Overproduction #diagnosis ... #signs #symptoms ... #endocrinology
Central Retinal Artery Occlusion: Pathogenesis and clinical findings
 • Inflammatory Disease: (i.e. GCA, SLE, GPA) ->
Retinal Artery Occlusion ... Retinal Artery Occlusion ... CentralRetinalArtery #Occlusion ... pathophysiology #ophthalmology ... #diagnosis #signs
Graves’ Disease: Pathogenesis and Clinical Findings
B & T lymphocyte mediated autoimmunity attack TSH receptor -> Continuous
the etiology Signs ... pathophysiology #endocin #endocrinology ... #symptoms #signs ... #diagnosis
Pituitary Mass Effects - Pathogenesis and Clinical Findings
 • Pituitary turnors are almost always a benign
following order; GH ... Signs / Symptoms ... #SideEffects #endocrinology
Retinoblastoma: Pathogenesis and clinical findings
 • Sporadic mutation -> One allele of RB1 tumor suppressor gene
Retinoblastoma Signs ... pathophysiology #ophthalmology ... #diagnosis #signs
Chronic Hypertensive Retinopathy: Pathogenesis and clinical findings

Ophthalmic Artery Hypertension
Stage 1: Mild/vasoconstrictive
 • Acute and chronic vasospasm
Hard Exudates • Occlusion ... pathophysiology #ophthalmology ... #diagnosis #signs
Diabetic Retinopathy: Pathogenesis and clinical findings

Mild Non-proliferative DR
 • Outpouchings of the weakened capillary walls or
infarcts from occlusions ... Retinopathy #Diabetes #ophthalmology ... #diagnosis #complications
Xeropthalmia: Pathogenesis and Ocular Manifestations

Decr Visual pigment -> Keratinization, thickening & non-wetting of the conjunctiva
pathophysiology #ophthalmology ... #diagnosis #signs