The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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pathophysiology symptoms growthhormone msk acute caudaequina excess feedbackloop glftap hyperthyroidism injury macroadenoma masseffects mnemonic neurology orthopedics overproduction sideeffects sjogrens spinalcord
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Growth Hormone (GH ... activates lipolysis Signs ... /Symptoms: • GH ... #FeedbackLoop #endocrinology ... pathophysiology #pituitary
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
GH excess prior ... Carpal Tunnel Syndrome ... Overproduction #diagnosis ... #signs #symptoms ... #endocrinology
Pituitary Mass Effects - Pathogenesis and Clinical Findings • Pituitary turnors are almost always a benign
Pituitary Mass Effects ... Pituitary adenomas ... following order; GH ... Signs / Symptoms ... #SideEffects #endocrinology
Primary Hyperthyroidism - Pathogenesis and Clinical Findings Note: Although rare, gestational diseases can lead to thyrotoxicosis due
Primary Hyperthyroidism ... production by the pituitary ... Signs/Symptoms: ... Pretibial myxedema #Primary ... Hyperthyroidism #endocrinology
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings • Primary Sjögren's is a solitary process whereas secondary Sjögren's
s Syndrome: Pathogenesis ... Sjögren's, the syndrome ... erythematosus (SLE) Signs ... Pathophysiology #Diagnosis ... #Signs #Symptoms
Acute Spinal Cord Injuries: Pathogenesis and clinical findings • Anterior Cord Syndrome -> Anterior spinal artery
Anterior Cord Syndrome ... Bladder retention -> Primarily ... hemicord lesion -> Primarily ... #diagnosis #pathophysiology ... #signs #symptoms
Cauda Equina Syndrome Causes: • Large lumbar degenerative disc herniation (central) • Severe lumbar spondylosis • Neoplasm
Cauda Equina Syndrome ... lumbar spine Signs ... reflexes) • Urinary ... pathophysiology #diagnosis ... #symptoms #signs
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