The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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pathophysiology diagnosis signs symptoms caudaequina feedbackloop glftap growthhormone macroadenoma masseffects mnemonic pagetsdisease sideeffects syndrome
Pituitary Mass Effects - Pathogenesis and Clinical Findings • Pituitary turnors are almost always a benign
Pituitary Mass Effects ... following order; GH ... Signs / Symptoms / Complications ... • Hypothalamic dysfunction ... #SideEffects #endocrinology
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Growth Hormone (GH ... /Symptoms: • GH ... abn lipid • GH ... #FeedbackLoop #endocrinology ... pathophysiology #pituitary
Cauda Equina Syndrome Causes: • Large lumbar degenerative disc herniation (central) • Severe lumbar spondylosis • Neoplasm
Signs / Symptoms / Complications ... bladder/bowel dysfunction ... CaudaEquina #Syndrome #MSK
Paget’s Disease: Complications Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation MSK
Paget’s Disease: Complications ... bone formation MSK ... causes middle ear dysfunction ... signs #symptoms #complications
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