The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
time of onset of GH ... GH excess prior ... GH excess after ... GrowthHormone #GH ... signs #symptoms #endocrinology
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Growth Hormone (GH ... /Symptoms: • GH ... abn lipid • GH ... excess: - ... #FeedbackLoop #endocrinology
Primary Hyperthyroidism - Pathogenesis and Clinical Findings

Note: Although rare, gestational diseases can lead to thyrotoxicosis due
thyrotoxicosis due to excess ... hyperthyroidism due to excess ... Hyperthyroidism #endocrinology
Lower Urinary Tract Infections: Complications
 - Infection damages the urinary tract epithelium causing fibroblast proliferation and
Bacteria gain access ... NH3) #Lower #UrinaryTractInfection
Lower Urinary Tract Infection: Pathogenesis and Clinical Findings

- Predisposing Factors:  Immunocompromised state, diabetes, elderly, female
Fecal bacteria access ... rare) #Lower #UrinaryTractInfection
Pituitary Mass Effects - Pathogenesis and Clinical Findings
 • Pituitary turnors are almost always a benign
following order; GH ... #SideEffects #endocrinology