The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Growth Hormone (GH ... /Symptoms: • GH ... deficiency: - Short ... #FeedbackLoop #endocrinology ... #pathophysiology
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
share the same pathophysiology ... GH excess prior ... Overproduction #diagnosis ... signs #symptoms #endocrinology ... #pathophysiology
Menstrual Cycle Physiology: Ovarian Cycle – Brief Overview
LH and FSH are required for follicular development and
ovulation -> LH supports ... MenstrualCycle #OvarianCycle ... #pathophysiology ... #menstruation #endocrinology
Low Ankle Sprain: Pathomechanics and Clinical Findings

Grading Ligament Sprains
l: Minimal ligament disruption, mild swelling & tenderness,
LowAnkleSprain #Sports ... #MSK #orthopedics ... Grading #Grades #Diagnosis ... #pathophysiology
Menstrual Cycle Physiology: the Uterine Cycle
The endometrium has receptors for ovarian hormones! Changes in structure and
built up, so a short ... built up, so a short ... MenstrualCycle #OvarianCycle ... #pathophysiology ... #UterineCycle #endocrinology
Menstrual Cycle Physiology: Correlating the Ovarian and Uterine Cycles
Note: Some charts show different relative levels of
days long) • Starts ... MenstrualCycle #OvarianCycle ... #pathophysiology ... #comparison #endocrinology
Distinguishing between Inflammatory and Degenerative joint disease
Inflammatory Joint Disease
 • Swelling stimulates joint nociceptors -> Pain
> Stiffness is short-lived ... Comparison #Versus #MSK ... JointDisease #JointPain #Diagnosis ... #pathophysiology
Posterior Cruciate Ligament (PCL) Injury: Pathogenesis and Clinical Findings
Classification of PCL Iniuries
 • Partial: Translation <
Some sort of end ... #PCL #Injury #MSK ... #Sports #pathophysiology ... classification #diagnosis