The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
lipolysis Signs/Symptoms ... metabolic abn #GrowthHormone ... #FeedbackLoop #endocrinology ... #pathophysiology
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
share the same pathophysiology ... fraction • HTN #GrowthHormone ... diagnosis #signs #symptoms ... #endocrinology ... #pathophysiology
Panic Disorder: Pathogenesis and clinical findings
Social Factors
 • Parenting and infant attachment
 • Childhood illness/abuse
 •
attachment • Childhood ... Psychological Symptoms ... PanicDisorder #Anxiety #BehavioralDisorder ... #Pathophysiology ... #diagnosis #symptoms
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings
Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
Signs/Symptoms/Complications ... #21HydroxylaseDeficiency #21OHD #pathophysiology ... #genetics #endocrinology ... #peds #pediatrics
Childhood Immunization Schedule: Why we immunize
 • Diphtheria Toxin -> URT inflammation causes pseudomembrane with hardened
Childhood Immunization ... hemorrhagic rash; symptoms ... discharge #Childhood ... Immunization #peds #pediatrics ... #pathophysiology
Conduct Disorder (CD): Pathogenesis and clinical findings
 - Must have >3 symptoms present in the past
- Must have >3 symptoms ... months, with >1 symptom ... when arising in childhood ... #Conduct #CD #BehavioralDisorder ... #Pathophysiology