The Calgary Guide to Understanding Disease @TheCalgaryGuide
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diagnosis symptoms gh ra rheumatoidarthritis temporal bakerscyst cranialarteritis criteria disease extraarticular feedbackloop giantcell giantcellarteritis henochscholeinpurpura hsp hyperthyroidism iga kawasaki msk
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
share the same pathophysiology ... fraction • HTN #GrowthHormone ... #diagnosis #signs ... #symptoms #endocrinology ... #pathophysiology
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
activates lipolysis Signs ... lipid • GH excess ... metabolic abn #GrowthHormone ... #FeedbackLoop #endocrinology ... #pathophysiology
Giant Cell (Temporal) Arteritis: Pathogenesis and investigations Risk Factors: - Unclear environmental triggers (may be viral, not
Cell (Temporal) Arteritis ... yrs old; F>M Signs ... #Pathophysiology ... #Diagnosis #Signs ... #Symptoms #Vasculitis
Primary Hyperthyroidism - Pathogenesis and Clinical Findings Note: Although rare, gestational diseases can lead to thyrotoxicosis due
thyrotoxicosis due to excess ... hyperthyroidism due to excess ... Signs/Symptoms: ... Hyperthyroidism #endocrinology ... #pathophysiology
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings - Infectious Agents - 50% have
IgA Vasculitis – ... Arthralgia's (common), arthritis ... #HSP #IgA #Vasculitis ... HenochScholeinPurpura #Pathophysiology ... #Diagnosis #Signs
Rheumatoid arthritis (RA): Extra-articular manifestations Skin: • Inflammation of skin (esp. over areas of stress) forms
Rheumatoid arthritis ... blood vessels (vasculitis ... RheumatoidArthritis #RA #pathophysiology ... #signs #symptoms
Giant Cell Arteritis (Polymyalgia Rheumatica and Cranial Arteritis): Pathogenesis and Clinical Findings - Morning Stiffness (>1
Giant Cell Arteritis ... Rheumatica and Cranial Arteritis ... CranialArteritis #Pathophysiology ... #Signs #Symptoms ... #Diagnosis #Vasculitis
Rheumatoid arthritis (RA): Pathogenesis and Joint diseases features • RA affects 1% of population, women >
Rheumatoid arthritis ... joint capsule exceeds ... Extra-articular signs ... RheumatoidArthritis #RA #pathophysiology ... #signs #symptoms
Kawasaki Disease: Clinical Findings Diagnostic Criteria - Fever and 4/5 of the following: • Conjunctivitis • Polymorphous
hands & feet Signs ... : - Coronary Arteritis ... Criteria #Diagnosis #Pathophysiology ... #Signs #Symptoms ... #Vasculitis
Popliteal (Baker’s) Cyst: Pathogenesis and clinical findings • Idiopathic • Meniscal Lesions • Osteoarthritis • Rheumatoid
• Rheumatoid Arthritis ... never aspirate/ excise ... BakersCyst #MSK #pathophysiology ... #signs #symptoms
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