The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Primary Hyperthyroidism - Pathogenesis and Clinical Findings

Note: Although rare, gestational diseases can lead to thyrotoxicosis due
production by the pituitary ... Signs/Symptoms: ... Hyperthyroidism #endocrinology ... #pathophysiology
Pituitary Mass Effects - Pathogenesis and Clinical Findings
 • Pituitary turnors are almost always a benign
Pituitary Mass Effects ... Pituitary adenomas ... Signs / Symptoms ... #SideEffects #endocrinology ... mnemonic #GLFTAP #pathophysiology
Myelopathy - Injury to the entire spinal cord - Signs and Symptoms
 • Ataxia (early sign)
spinal cord - Signs ... and Symptoms ... Ataxia (early sign ... weakness (late sign ... #symptoms #msk
Cubital Tunnel Syndrome: Pathogenesis and clinical findings

 • Paresthesia of 5th and medial half of 4th
test • + Tinel sign ... • + Froment's sign ... Syndrome #Diagnosis #pathophysiology ... #signs #symptoms ... #msk
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
activates lipolysis Signs ... /Symptoms: • GH ... #FeedbackLoop #endocrinology ... #pathophysiology ... #pituitary
Radiculopathy: Signs and Symptoms
 • Back/Neck Pain
 • Decr Range of motion
 • Abnormal posturing
 •
Radiculopathy: Signs ... and Symptoms ... Radiculopathy #MSK ... #diagnosis #signs ... #symptoms #pathophysiology
Stress Fracture: Pathogenesis and clinical findings
Abnormal biomechanics, Repetitive impact activities
=> Repetitive subthreshold mechanical loading
=> Bone strain
=>
StressFractures #msk ... #orthopedics #pathophysiology ... #symptoms #signs
Graves’ Disease: Pathogenesis and Clinical Findings
B & T lymphocyte mediated autoimmunity attack TSH receptor -> Continuous
the etiology Signs ... /Symptoms: - Pretibial ... GravesDisease #pathophysiology ... #endocin #endocrinology ... #symptoms #signs
Spondylolysis & Spondylolisthesis: Pathogenesis and Clinical Findings

Pars interarticularis stress fracture (spondylolysis) - most frequently in the
XR — scotty dog sign ... Spondylolisthesis #MSK ... #diagnosis #pathophysiology ... #signs #symptoms
Menstrual Cycle Physiology: Ovarian Cycle – Brief Overview
LH and FSH are required for follicular development and
- FSH from pituitary ... - LH from pituitary ... LH release from pituitary ... #OvarianCycle #pathophysiology ... #menstruation #endocrinology