The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Selective Serotonin Reuptake Inhibitors: Mechanisms and Side Effects
 • Serotonin Syndrome:
   - Autonomic Hyperactivity:
Serotonin Reuptake Inhibitors ... : Mechanisms and ... #Pathophysiology ... #SideEffects #Psychiatry ... Diagnosis #Signs #Symptoms
Serotonin-Norepinephrine Reuptake Inhibitors(SNRIs): Mechanisms and Side Effects

Withdrawal: Dizziness, Diarrhea, Insomnia, Nausea, Vomiting
Serotonin Syndrome - Potentially Life
Serotonin-Norepinephrine Reuptake Inhibitors ... (SNRIs): Mechanisms ... #Pathophysiology ... #SideEffects #Psychiatry ... Diagnosis #Signs #Symptoms
Menstrual Cycle Physiology: Ovarian Cycle – Brief Overview
LH and FSH are required for follicular development and
- FSH from pituitary ... - LH from pituitary ... MenstrualCycle #OvarianCycle ... #pathophysiology ... #menstruation #endocrinology
Menstrual Cycle Physiology: Ovarian Cycle – Follicular Phase Explained
Early Follicular Phase (Days 0-5)
 • Granulosa cells
continue growing (mechanism ... estrogen secretion -> inhibits ... MenstrualCycle #OvarianCycle ... #pathophysiology ... FollicularPhase #endocrinology
Menstrual Cycle Physiology: Ovarian Cycle – Ovulation Explained

Around Day 14, estrogen exerts sudden +++ positive feedback
on the anterior pituitary ... MenstrualCycle #OvarianCycle ... #pathophysiology ... #Ovulation #endocrinology
Pituitary Mass Effects - Pathogenesis and Clinical Findings
 • Pituitary turnors are almost always a benign
Pituitary Mass Effects ... Pituitary adenomas ... Signs / Symptoms ... #SideEffects #endocrinology ... mnemonic #GLFTAP #pathophysiology
Primary Hyperthyroidism - Pathogenesis and Clinical Findings

Note: Although rare, gestational diseases can lead to thyrotoxicosis due
production by the pituitary ... Signs/Symptoms: ... Hyperthyroidism #endocrinology ... #pathophysiology
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
lipolysis Signs/Symptoms ... #FeedbackLoop #endocrinology ... #pathophysiology ... #pituitary
First Generation Anti-Psychotics: Mechanisms and Side Effects
Typical/Conventional Anti-Psychotics - Examples: Haloperidol, Chlorpromazine

ACh M1 antagonist - Block
Anti-Psychotics: Mechanisms ... Hypothalamus -> Pituitary ... Extrapyramidal Symptoms ... FirstGeneration #Mechanisms ... pharmacology #diagnosis #psychiatry
Menstrual Cycle Physiology: Ovarian Cycle – Luteal Phase Explained
 • The LH surge can be thought
hypothalamus and anterior pituitary ... MenstrualCycle #OvarianCycle ... #pathophysiology ... #LutealPhase #endocrinology