The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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pathophysiology diagnosis symptoms gh anterior dislocation feedbackloop hyperthyroidism msk orthopedics overproduction pituitary primary ra rheumatoidarthritis shoulder
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
Growth Hormone Excess ... GH excess prior ... fraction • HTN #GrowthHormone ... #diagnosis #signs ... #symptoms #endocrinology
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
activates lipolysis Signs ... lipid • GH excess ... metabolic abn #GrowthHormone ... #FeedbackLoop #endocrinology
Primary Hyperthyroidism - Pathogenesis and Clinical Findings Note: Although rare, gestational diseases can lead to thyrotoxicosis due
thyrotoxicosis due to excess ... hyperthyroidism due to excess ... Signs/Symptoms: ... Hyperthyroidism #endocrinology
Anterior Shoulder Dislocation: Pathogenesis, clinical, and radiographic findings Trauma, Fall on, outstretched arm, Overhead throwing => Abduction
joint => Force exceeds ... to glenoid -> Acute ... Dislocation #Diagnosis #signs
Rheumatoid arthritis (RA): Pathogenesis and Joint diseases features • RA affects 1% of population, women >
• Non-specific Acute-phase ... joint capsule exceeds ... Extra-articular signs ... pathophysiology #signs
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