The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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pathophysiology diagnosis signs psychiatry pediatrics peds riskfactors syndrome 21hydroxylasedeficiency 21ohd alzheimersdisease anorexianervosa bulimianervosa caudaequina dementia diabetes diabeticketoacidosis dka geriatrics glftap
Obsessive-Compulsive Disorder (OCD): Pathogenesis and clinical findings Psychological Hypothesis • Cognitive behavioral model: Emotional disturbance arising from
disturbance arising from dysfunctional ... Structural model: Dysfunction ... regions suspected Genetics ... Psychiatry #Signs #Symptoms
Alzheimer’s Disease: Pathogenesis and Clinical Findings Risk factor for Late Onset Alzheimer's (99% of cases): - Increasing
chromosome 21) Signs / Symptoms ... / Complications ... Executive planning dysfunction ... concentration • Motor dysfunction ... diagnosis #signs #symptoms
Prader-Willi Syndrome: Pathogenesis and clinical findings • Maternal uniparental disomy: inheriting 2 copies of maternal chromosome
Syndrome Signs/Symptoms ... /Complications: ... PraderWilli #Syndrome #genetics
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
Signs/Symptoms/Complications ... pathophysiology #genetics ... #endocrinology
Pituitary Mass Effects - Pathogenesis and Clinical Findings • Pituitary turnors are almost always a benign
Signs / Symptoms ... / Complications ... • Hypothalamic dysfunction ... #SideEffects #endocrinology
Cauda Equina Syndrome Causes: • Large lumbar degenerative disc herniation (central) • Severe lumbar spondylosis • Neoplasm
spine Signs / Symptoms ... / Complications ... bladder/bowel dysfunction ... pathophysiology #diagnosis #symptoms
Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings • Note: in DKA, body K+ is lost
Signs/Symptoms/Complications ... pathophysiology #endocrinology
Keratoconus: Pathogenesis and Clinical Findings Genetics • Family history of keratoconus • Ehlers-Danlos syndrome • Down, Turner,
Clinical Findings Genetics ... Keratoconus Signs / Symptoms ... / Complications
Paget’s Disease: Complications Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation MSK
Paget’s Disease: Complications ... causes middle ear dysfunction ... diagnosis #signs #symptoms ... #complications
Anorexia Nervosa: Pathogenesis and Risk Factors Biological Risk Factors • Gender: F > M • Genetics: concordance
Gender: F > M • Genetics ... abuse, familial dysfunction ... diagnosis #signs #symptoms
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