The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Menstrual Cycle Physiology: The Hypothalamic-Pituitary-Ovarian Axis
Estrogen, when released:
 • Negatively feeds back on the hypothalamus and
The Hypothalamic-Pituitary-Ovarian ... hypothalamus and anterior pituitary ... #MenstrualCycle ... HypothalamicPituitary #endocrinology ... #feedback
Menstrual Cycle Physiology: Ovarian Cycle – Ovulation Explained

Around Day 14, estrogen exerts sudden +++ positive feedback
sudden +++ positive feedback ... on the anterior pituitary ... negative to positive feedback ... for clarity) #MenstrualCycle ... pathophysiology #Ovulation #endocrinology
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Feedback Loop: Growth ... activates lipolysis Signs ... #FeedbackLoop #endocrinology ... pathophysiology #pituitary
Menstrual Cycle Physiology: Correlating the Ovarian and Uterine Cycles
Note: Some charts show different relative levels of
on the anterior pituitary ... #UterineCycle #MenstrualCycle ... pathophysiology #comparison ... #endocrinology