The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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signs symptoms complications hypersensitivityreaction otitismedia ankylosingspondylitis benign bph centralretinalartery cholesteatoma crao extraarticular hyperplasia management manifestations mastoiditis middleear occlusion ophthalmology otology
Type I Hypersensitivity: Pathogenesis and clinical findings Definition: Production of lgE Antibodies that bind to harmless allergens
leading to an allergic ... Sensitization" to Allergen ... Complications: • Acute ... conjunctivitis • Anaphylaxis ... #Immunology #pathophysiology
Type IV Hypersensitivity: Pathogenesis and clinical findings Definition: Unique because it is entirely T-Cell mediated; exposure to
mediated; exposure to allergen ... Allergic reaction ... Initial exposure to allergen ... cells or CTLs -> Inflammation ... #Immunology #pathophysiology
Anaphylaxis: Signs and Symptoms Anaphylaxis: when any egg of three conditions is met: 1. Acute onset of skin/mucosal
Acute onset of skin ... exposure to known allergen ... symptoms in the acute ... #pathophysiology ... #immunology #diagnosis
Anaphylaxis: Treatments (Acute) Additional Info: • IV steroids may be considered for prevention of late phase reactions.
Anaphylaxis: Treatments ... (Acute) Additional ... provided, as well as allergy ... Treatments #Management #pathophysiology ... #immunology
X-Linked Agammaglobulinemia: Pathogenesis and clinical findings The epidemiology of this disease is 1/340,000 births and roughly double
X-Linked Agammaglobulinemia ... 40% of patients diagnosed ... common antigens #Agammaglobulinemia ... #XLinked #pathophysiology ... #immunology
Acute Rheumatic Fever: Pathogenesis and Clinical Findings Delayed autoimmune reaction -> Molecular mimicry -> GAS antigen cross-reacts with host ->
Acute Rheumatic ... Tissue injury and inflammation ... , Carditis #Acute ... RheumaticFever #pathophysiology ... #diagnosis #signs
Mastoiditis: Pathogenesis and clinical findings Acute or Chronic Otitis Media -> Stage 1: Hyperemeia of the mastoid
clinical findings Acute ... mastoid air cells (inflammation ... mucosa leads to inflammation ... #Mastoiditis #pathophysiology ... signs #symptoms #diagnosis
Acute Otitis Media: Pathogenesis and Clinical Findings (in Children) Upper Respiratory Tract Infection: - Bacterial: Streptococcus
Acute Otitis Media ... bacterial. => Inflammation ... #OtitisMedia #pathophysiology ... #diagnosis #symptoms
Acute Otitis Media: Complications Infection and inflammation of the middle ear - Prolonged obstruction of e. tube
Acute Otitis Media ... Infection and inflammation ... Balance Problems #Acute ... Complications #pathophysiology ... symptoms #signs #diagnosis
Central Retinal Artery Occlusion: Pathogenesis and clinical findings • Inflammatory Disease: (i.e. GCA, SLE, GPA) ->
viscosity and inflammation ... trucking" • Acute ... Occlusion #CRAO #pathophysiology ... ophthalmology #diagnosis
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