The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Anaphylaxis: Pathogenesis
Anaphylaxis is a Type 1 hypersensitivity reaction
While the primary mechanism of anaphylaxis is mast cell
Anaphylaxis: Pathogenesis ... Anaphylaxis is ... primary mechanism of anaphylaxis ... #Anaphylaxis ... pathophysiology #immunology
Anaphylaxis: Signs and Symptoms
Anaphylaxis: when any egg of three conditions is met:
1. Acute onset of skin/mucosal
Anaphylaxis: Signs ... and Symptoms Anaphylaxis ... Angioedema #Anaphylaxis ... pathophysiology #immunology
Inflammatory Cascade: Pathogenesis and Clinical Findings
Continued Innate Immunity
 • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
destruction), promote inflammation ... Inflammatory #Cascade #Inflammation ... pathophysiology #immunology
Rheumatoid arthritis (RA): Extra-articular manifestations
Skin: 
 • Inflammation of skin (esp. over areas of stress) forms
manifestations Skin: • Inflammation ... Eyes: • Globe inflammation ... audible Lungs: • Inflammation ... on CXR • RA inflammation ... symptoms #diagnosis #ExtraArticular
Anaphylaxis: Treatments (Acute)
Additional Info:
 • IV steroids may be considered for prevention of late phase reactions.
Anaphylaxis: Treatments ... Ventolin inhaler #Anaphylaxis ... pathophysiology #immunology
Type IV Hypersensitivity: Pathogenesis and clinical findings
Definition: Unique because it is entirely T-Cell mediated; exposure to
cells or CTLs -> Inflammation ... HypersensitivityReaction #Allergy #Immunology
Type I Hypersensitivity: Pathogenesis and clinical findings
Definition: Production of lgE Antibodies that bind to harmless allergens
conjunctivitis • Anaphylaxis ... HypersensitivityReaction #Allergy #Immunology
C5-C9 Deficiency - Pathogenesis and Clinical Findings
Note:
 • Risk of invasive meningococcal disease is 1000-10000x higher
Inflammation ... pathophysiology #immunology
Ankylosing Spondylitis: Extra-articular Manifestations
 • Ocular - Inflammation of the iris, the anterior part of the
Manifestations • Ocular - Inflammation ... • Cardiac - Inflammation ... - Ligamentous inflammation ... Respiratory (rare) - Inflammation ... AnkylosingSpondylitis #Extraarticular