The Calgary Guide to Understanding Disease @TheCalgaryGuide
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pathophysiology diagnosis signs symptoms complications inflammatory ra rheumatoidarthritis allergy ankylosingspondylitis c5c9deficiency cascade comparison complement degenerative hypersensitivityreaction jointdisease jointpain lupus msk
Rheumatoid arthritis (RA): Extra-articular manifestations Skin: • Inflammation of skin (esp. over areas of stress) forms
Extra-articular manifestations ... Skin: • Inflammation ... Eyes: • Globe inflammation ... on CXR • RA inflammation ... symptoms #diagnosis #ExtraArticular
Inflammatory Cascade: Pathogenesis and Clinical Findings Continued Innate Immunity • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
destruction), promote inflammation ... Inflammatory #Cascade #Inflammation ... pathophysiology #immunology
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Mucocutaneous Manifestations ... scaling that extend inflammation ... -> Incr local inflammation ... follicles due to inflammation ... Mucocutaneous #Manifestations
Type IV Hypersensitivity: Pathogenesis and clinical findings Definition: Unique because it is entirely T-Cell mediated; exposure to
cells or CTLs -> Inflammation ... HypersensitivityReaction #Allergy #Immunology
Ankylosing Spondylitis: Extra-articular Manifestations • Ocular - Inflammation of the iris, the anterior part of the
Extra-articular Manifestations ... • Ocular - Inflammation ... • Cardiac - Inflammation ... AnkylosingSpondylitis #Extraarticular ... #Manifestations
C5-C9 Deficiency - Pathogenesis and Clinical Findings Note: • Risk of invasive meningococcal disease is 1000-10000x higher
• Inflammation ... pathophysiology #immunology
Distinguishing between Inflammatory and Degenerative joint disease Inflammatory Joint Disease • Swelling stimulates joint nociceptors -> Pain
Swollen Joints • Inflammation ... Extra-articular manifestations ... mild synovial inflammation
Rheumatoid arthritis (RA): Pathogenesis and Joint diseases features • RA affects 1% of population, women >
Extra-articular manifestations ... etc • Systemic inflammation
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