The Calgary Guide to Understanding Disease @TheCalgaryGuide
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pathophysiology signs symptoms complications ophthalmology urology acute benign bph cellulitis extraarticular inflammatory manifestations msk otitismedia prostate prostatic psoriaticarthritis psychiatry ra
Inflammatory Cascade: Pathogenesis and Clinical Findings Continued Innate Immunity • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
destruction), promote inflammation ... Inflammatory #Cascade #Inflammation ... pathophysiology #immunology
Benign Prostatic Hyperplasia: Pathogenesis and Medications Aging -> Increased Testosterone -> Testosterone metabolized into DHT by type
Benign Prostatic Hyperplasia ... cell nuclei -> Hyperplasia ... smooth-muscle hyperplasia ... Decreased Prostatic inflammation ... Benign #Prostatic #Hyperplasia
Type IV Hypersensitivity: Pathogenesis and clinical findings Definition: Unique because it is entirely T-Cell mediated; exposure to
cells or CTLs -> Inflammation ... HypersensitivityReaction #Allergy #Immunology
Rheumatoid arthritis (RA): Extra-articular manifestations Skin: • Inflammation of skin (esp. over areas of stress) forms
manifestations Skin: • Inflammation ... Eyes: • Globe inflammation ... audible Lungs: • Inflammation ... on CXR • RA inflammation ... signs #symptoms #diagnosis
Orbital Cellulitis: Pathogenesis and Clinical Findings Definitions: a. Chemosis: Edema of the bulbar conjunctiva b. Panopthalmitis: inflammation of all
Panopthalmitis: inflammation ... Endopthalmitis: inflammation ... ) -> Localized inflammation ... Induration, Warmth • Inflammation ... ophthalmology #diagnosis
Graves’ Disease: Pathogenesis and Clinical Findings B & T lymphocyte mediated autoimmunity attack TSH receptor -> Continuous
Thyroid gland hyperplasia ... symptoms #signs #diagnosis
Anaphylaxis: Signs and Symptoms Anaphylaxis: when any egg of three conditions is met: 1. Acute onset of skin/mucosal
pathophysiology #immunology ... #diagnosis #signs
Reactive Arthritis • Inflammation of joints (commonly large joints) - Asymmetric Oligoarthritis: Joint
Arthritis • Inflammation ... Effusions • Inflammation ... pathophysiology #diagnosis
Mastoiditis: Pathogenesis and clinical findings Acute or Chronic Otitis Media -> Stage 1: Hyperemeia of the mastoid
mastoid air cells (inflammation ... mucosa leads to inflammation ... mastoid air cells (inflammation ... (infection or inflammation ... signs #symptoms #diagnosis
C5-C9 Deficiency - Pathogenesis and Clinical Findings Note: • Risk of invasive meningococcal disease is 1000-10000x higher
• Inflammation ... pathophysiology #immunology
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