The Calgary Guide to Understanding Disease @TheCalgaryGuide
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diagnosis signs complications ophthalmology pediatrics peds urology acute benign bph cellulitis endocrinology extraarticular genetics manifestations otitismedia prostate prostatic psoriaticarthritis psychiatry
Inflammatory Cascade: Pathogenesis and Clinical Findings Continued Innate Immunity • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
destruction), promote inflammation ... Inflammatory #Cascade #Inflammation ... #pathophysiology ... #immunology
Anaphylaxis: Signs and Symptoms Anaphylaxis: when any egg of three conditions is met: 1. Acute onset of skin/mucosal
Anaphylaxis: Signs and Symptoms ... Rapid onset of symptoms ... Signs / Symptoms ... #Anaphylaxis #pathophysiology ... #immunology #diagnosis
Graves’ Disease: Pathogenesis and Clinical Findings B & T lymphocyte mediated autoimmunity attack TSH receptor -> Continuous
Thyroid gland hyperplasia ... etiology Signs/Symptoms ... GravesDisease #pathophysiology ... endocrinology #symptoms
Type IV Hypersensitivity: Pathogenesis and clinical findings Definition: Unique because it is entirely T-Cell mediated; exposure to
cells or CTLs -> Inflammation ... HypersensitivityReaction #Allergy #Immunology ... #pathophysiology
Benign Prostatic Hyperplasia: Pathogenesis and Medications Aging -> Increased Testosterone -> Testosterone metabolized into DHT by type
Benign Prostatic Hyperplasia ... cell nuclei -> Hyperplasia ... smooth-muscle hyperplasia ... Decreased Prostatic inflammation ... #Prostate #Pathophysiology
Reactive Arthritis • Inflammation of joints (commonly large joints) - Asymmetric Oligoarthritis: Joint
Arthritis • Inflammation ... Effusions • Inflammation ... ReactiveArthritis #pathophysiology ... diagnosis #signs #symptoms
Rheumatoid arthritis (RA): Extra-articular manifestations Skin: • Inflammation of skin (esp. over areas of stress) forms
manifestations Skin: • Inflammation ... Eyes: • Globe inflammation ... on CXR • RA inflammation ... RheumatoidArthritis #RA #pathophysiology ... #signs #symptoms
Orbital Cellulitis: Pathogenesis and Clinical Findings Definitions: a. Chemosis: Edema of the bulbar conjunctiva b. Panopthalmitis: inflammation of all
Panopthalmitis: inflammation ... Endopthalmitis: inflammation ... ) -> Localized inflammation ... Orbital #Cellulitis #pathophysiology ... diagnosis #signs #symptoms
Benign Prostatic Hyperplasia: Pathogenesis and Clinical Findings Hormonal alterations (result of aging process) ->
Benign Prostatic Hyperplasia ... FGF-related proteins) Inflammation ... granulocytes) -> Prostate Inflammation ... Benign #Prostatic #Hyperplasia ... #Prostate #Pathophysiology
Retinoblastoma: Pathogenesis and clinical findings • Sporadic mutation -> One allele of RB1 tumor suppressor gene
Retinoblastoma Signs / Symptoms ... reflex) • Orbital inflammation ... Retinoblastoma #pathophysiology ... diagnosis #signs #symptoms
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