The Calgary Guide to Understanding Disease @TheCalgaryGuide
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diagnosis signs symptoms complications urology allergy hyperplasia hypersensitivityreaction manifestations msk ophthalmology pharmacology prostate prostatic adhesivecapsulitis anaphylaxis ankylosingspondylitis benzodiazepine bzd c5c9deficiency
Inflammatory Cascade: Pathogenesis and Clinical Findings Continued Innate Immunity • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
Inflammatory Cascade ... destruction), promote inflammation ... #Cascade #Inflammation ... #pathophysiology ... #immunology
Anaphylaxis: Pathogenesis Anaphylaxis is a Type 1 hypersensitivity reaction While the primary mechanism of anaphylaxis is mast cell
production of inflammatory ... Recruitment of inflammatory ... #Anaphylaxis #pathophysiology ... #immunology
Type IV Hypersensitivity: Pathogenesis and clinical findings Definition: Unique because it is entirely T-Cell mediated; exposure to
cells or CTLs -> Inflammation ... HypersensitivityReaction #Allergy #Immunology ... #pathophysiology
Benign Prostatic Hyperplasia: Pathogenesis and Clinical Findings Hormonal alterations (result of aging process) ->
Benign Prostatic ... activation of inflammatory ... bladder stones #BPH ... #Benign #Prostatic ... Hyperplasia #Prostate #Pathophysiology
Benign Prostatic Hyperplasia: Pathogenesis and Medications Aging -> Increased Testosterone -> Testosterone metabolized into DHT by type
Benign Prostatic ... Decreased Prostatic inflammation ... #BPH #Benign ... Hyperplasia #Prostate #Pathophysiology
Type I Hypersensitivity: Pathogenesis and clinical findings Definition: Production of lgE Antibodies that bind to harmless allergens
release the pro-inflammatory ... secretion • Inflammatory ... HypersensitivityReaction #Allergy #Immunology ... #pathophysiology
Distinguishing between Inflammatory and Degenerative joint disease Inflammatory Joint Disease • Swelling stimulates joint nociceptors -> Pain
Distinguishing between Inflammatory ... joint disease Inflammatory ... Swollen Joints • Inflammation ... mild synovial inflammation ... JointPain #Diagnosis #pathophysiology
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
cytokines -> localized inflammatory ... scaling that extend inflammation ... -> Incr local inflammation ... follicles due to inflammation ... Manifestations #pathophysiology
Lower Urinary Tract Infections: Complications - Infection damages the urinary tract epithelium causing fibroblast proliferation and
Bacterial toxins and inflammation ... in a systemic inflammatory ... UrinaryTractInfection #LUTI #Pathophysiology
Periorbital Cellulitis: Pathogenesis and Clinical Findings Definitions: a. Dacryoadenitis: infection of the lacrimal glands b. Conjunctivitis: inflammation of the
Conjunctivitis: inflammation ... Chalazion: a benign ... localized infection or inflammation ... Periorbital #Cellulitis #pathophysiology
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