The Calgary Guide to Understanding Disease @TheCalgaryGuide
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pathophysiology diagnosis signs complications manifestations msk urology adhesivecapsulitis ankylosingspondylitis benign cascade centralretinalartery comparison crao degenerative extraarticular frozenshoulder hyperplasia incontinence jointdisease
Inflammatory Cascade: Pathogenesis and Clinical Findings Continued Innate Immunity • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
Inflammatory Cascade ... destruction), promote inflammation ... cell activity #Inflammatory ... #Cascade #Inflammation ... pathophysiology #immunology
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... cytokines -> localized inflammatory ... Subacute cutaneous lupus ... Phenomenon #Lupus ... diagnosis #signs #symptoms
Distinguishing between Inflammatory and Degenerative joint disease Inflammatory Joint Disease • Swelling stimulates joint nociceptors -> Pain
Distinguishing between Inflammatory ... joint disease Inflammatory ... Swollen Joints • Inflammation ... Rheumatoid arthritis, Lupus ... mild synovial inflammation
Mastoiditis: Pathogenesis and clinical findings Acute or Chronic Otitis Media -> Stage 1: Hyperemeia of the mastoid
mastoid air cells (inflammation ... mucosa leads to inflammation ... mastoid air cells (inflammation ... : Extension of inflammatory ... pathophysiology #signs #symptoms
Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings • Primary (Idiopathic): Unknown etiology, but associated
shoulder joint inflammation ... as post-inflammatory ... shoulder joint inflammation ... stop, but post-inflammatory ... pathophysiology #diagnosis #symptoms
Benign Prostatic Hyperplasia: Pathogenesis and Clinical Findings Hormonal alterations (result of aging process) ->
FGF-related proteins) Inflammation ... granulocytes) -> Prostate Inflammation ... activation of inflammatory ... bladder stones #BPH ... Urology #Signs #Symptoms
Mixed Urinary Incontinence: Pathogenesis and Clinical Findings Urgency Urinary Incontinence (UUI) -> Urinary leakage preceded by a
tumour, stone, BPH ... (neurogenic), inflammation ... Pathophysiology #Signs #Symptoms
Central Retinal Artery Occlusion: Pathogenesis and clinical findings • Inflammatory Disease: (i.e. GCA, SLE, GPA) ->
clinical findings • Inflammatory ... viscosity and inflammation ... diagnosis #signs #symptoms
Rheumatoid arthritis (RA): Pathogenesis and Joint diseases features • RA affects 1% of population, women >
• Rate of inflammatory ... etc • Systemic inflammation ... pathophysiology #signs #symptoms
Psoriatic Arthritis: Complications • Ocular - Inflammation of middle layer of the eye (the uvea, which
• Ocular - Inflammation ... Valvular disease - Inflammatory ... WBCs activity -> inflammation ... diagnosis #signs #symptoms
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