The Calgary Guide to Understanding Disease @TheCalgaryGuide
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diagnosis signs complications benign hyperplasia manifestations prostate prostatic adhesivecapsulitis ankylosingspondylitis cascade centralretinalartery crao extraarticular frozenshoulder incontinence lupus mastoiditis medications mixed
Inflammatory Cascade: Pathogenesis and Clinical Findings Continued Innate Immunity • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
Inflammatory Cascade ... destruction), promote inflammation ... #Cascade #Inflammation ... #pathophysiology ... #immunology
Benign Prostatic Hyperplasia: Pathogenesis and Clinical Findings Hormonal alterations (result of aging process) ->
FGF-related proteins) Inflammation ... activation of inflammatory ... bladder stones #BPH ... Hyperplasia #Prostate #Pathophysiology ... #Urology #Signs
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
cytokines -> localized inflammatory ... scaling that extend inflammation ... -> Incr local inflammation ... Manifestations #pathophysiology ... diagnosis #signs #symptoms
Mastoiditis: Pathogenesis and clinical findings Acute or Chronic Otitis Media -> Stage 1: Hyperemeia of the mastoid
mucosa leads to inflammation ... : Extension of inflammatory ... #Mastoiditis #pathophysiology ... #signs #symptoms ... #diagnosis #otology
Mixed Urinary Incontinence: Pathogenesis and Clinical Findings Urgency Urinary Incontinence (UUI) -> Urinary leakage preceded by a
tumour, stone, BPH ... (neurogenic), inflammation ... Incontinence #Mixed #Pathophysiology ... #Signs #Symptoms ... #Urology #Diagnosis
Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings • Primary (Idiopathic): Unknown etiology, but associated
shoulder joint inflammation ... as post-inflammatory ... shoulder joint inflammation ... FrozenShoulder #pathophysiology ... #diagnosis #symptoms
Central Retinal Artery Occlusion: Pathogenesis and clinical findings • Inflammatory Disease: (i.e. GCA, SLE, GPA) ->
clinical findings • Inflammatory ... viscosity and inflammation ... Occlusion #CRAO #pathophysiology ... diagnosis #signs #symptoms
Benign Prostatic Hyperplasia: Pathogenesis and Medications Aging -> Increased Testosterone -> Testosterone metabolized into DHT by type
Decreased Prostatic inflammation ... #BPH #Benign ... Hyperplasia #Prostate #Pathophysiology ... #Pharmacology #Urology
Rheumatoid arthritis (RA): Pathogenesis and Joint diseases features • RA affects 1% of population, women >
• Rate of inflammatory ... etc • Systemic inflammation ... RheumatoidArthritis #RA #pathophysiology ... #signs #symptoms
Psoriatic Arthritis: Complications • Ocular - Inflammation of middle layer of the eye (the uvea, which
• Ocular - Inflammation ... Valvular disease - Inflammatory ... WBCs activity -> inflammation ... PsoriaticArthritis #pathophysiology ... diagnosis #signs #symptoms
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