The Calgary Guide to Understanding Disease @TheCalgaryGuide
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symptoms complications msk ophthalmology psychiatry vasculitis acute bulimianervosa cellulitis extraarticular manifestations otitismedia psoriaticarthritis ra rheumatoidarthritis syndrome urology adhesivecapsulitis agammaglobulinemia alcohol
Inflammatory Cascade: Pathogenesis and Clinical Findings Continued Innate Immunity • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
Inflammatory Cascade ... destruction), promote inflammation ... #Cascade #Inflammation ... #pathophysiology ... #immunology
Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings • Primary (Idiopathic): Unknown etiology, but associated
as post-inflammatory ... FrozenShoulder #pathophysiology ... #diagnosis #symptoms ... #signs #stages ... #staging #msk
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
cytokines -> localized inflammatory ... with keratotic scaling ... that extend inflammation ... Manifestations #pathophysiology ... #diagnosis #signs
Mastoiditis: Pathogenesis and clinical findings Acute or Chronic Otitis Media -> Stage 1: Hyperemeia of the mastoid
Otitis Media -> Stage ... : Extension of inflammatory ... #Mastoiditis #pathophysiology ... #signs #symptoms ... #diagnosis #otology
Anaphylaxis: Signs and Symptoms Anaphylaxis: when any egg of three conditions is met: 1. Acute onset of skin/mucosal
Anaphylaxis: Signs ... phase symptoms Signs ... #Anaphylaxis #pathophysiology ... #immunology #diagnosis ... #signs #symptoms
Radiculopathy: Signs and Symptoms • Back/Neck Pain • Decr Range of motion • Abnormal posturing •
Radiculopathy: Signs ... : -> Shooting, stabbing ... Radiculopathy #MSK #diagnosis ... #signs #symptoms ... #pathophysiology
Type IV Hypersensitivity: Pathogenesis and clinical findings Definition: Unique because it is entirely T-Cell mediated; exposure to
T-Cell activation takes ... cells or CTLs -> Inflammation ... HypersensitivityReaction #Allergy #Immunology ... #pathophysiology
Central Retinal Artery Occlusion: Pathogenesis and clinical findings • Inflammatory Disease: (i.e. GCA, SLE, GPA) ->
clinical findings • Inflammatory ... viscosity and inflammation ... Occlusion #CRAO #pathophysiology ... ophthalmology #diagnosis ... #signs #symptoms
Reactive Arthritis • Inflammation of joints (commonly large joints) - Asymmetric Oligoarthritis: Joint
Arthritis • Inflammation ... Effusions • Inflammation ... ReactiveArthritis #pathophysiology ... #diagnosis #signs
Distinguishing between Inflammatory and Degenerative joint disease Inflammatory Joint Disease • Swelling stimulates joint nociceptors -> Pain
Lots of fluid, takes ... Swollen Joints • Inflammation ... mild synovial inflammation ... JointDisease #JointPain #Diagnosis ... #pathophysiology
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