The Calgary Guide to Understanding Disease @TheCalgaryGuide
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pathophysiology complications diagnosis signs symptoms ankylosingspondylitis benign bph c5c9deficiency cascade extraarticular hyperplasia lower luti manifestations prostatic urinarytractinfection urology
Inflammatory Cascade: Pathogenesis and Clinical Findings Continued Innate Immunity • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
Inflammatory Cascade ... dead tissue • Complement ... activation of complement ... #Cascade #Inflammation ... pathophysiology #immunology
Benign Prostatic Hyperplasia: Pathogenesis and Clinical Findings Hormonal alterations (result of aging process) ->
Benign Prostatic ... FGF-related proteins) Inflammation ... Inflammation: Incr ... activation of inflammatory ... Urgency, nocturia, incontinence
Lower Urinary Tract Infections: Complications - Infection damages the urinary tract epithelium causing fibroblast proliferation and
Bacterial toxins and inflammation ... in a systemic inflammatory ... urethra travel to prostate ... via prostatic ducts
C5-C9 Deficiency - Pathogenesis and Clinical Findings Note: • Risk of invasive meningococcal disease is 1000-10000x higher
is rare Normal complement ... response: The complement ... activation -> Complement ... • Inflammation ... pathophysiology #immunology
Ankylosing Spondylitis: Extra-articular Manifestations • Ocular - Inflammation of the iris, the anterior part of the
photophobia • GI - Inflammatory ... endoscopy (Not Inflammatory ... • Cardiac - Inflammation ... - Ligamentous inflammation ... Bladder and bowel incontinence
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