The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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diagnosis pathophysiology signs complications urology ankylosingspondylitis benign comparison degenerative extraarticular hyperplasia jointdisease jointpain mixed msk mucocutaneous prostate prostatic ra rheumatoidarthritis
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... Manifestations ... cytokines -> localized inflammatory ... Mucocutaneous #Manifestations ... diagnosis #signs #symptoms
Mixed Urinary Incontinence: Pathogenesis and Clinical Findings Urgency Urinary Incontinence (UUI) -> Urinary leakage preceded by a
Mixed Urinary Incontinence ... Urgency Urinary Incontinence ... tumour, stone, BPH ... (neurogenic), inflammation ... Pathophysiology #Signs #Symptoms
Distinguishing between Inflammatory and Degenerative joint disease Inflammatory Joint Disease • Swelling stimulates joint nociceptors -> Pain
joint disease Inflammatory ... Swollen Joints • Inflammation ... Rheumatoid arthritis, Lupus ... Extra-articular manifestations ... mild synovial inflammation
Ankylosing Spondylitis: Extra-articular Manifestations • Ocular - Inflammation of the iris, the anterior part of the
Extra-articular Manifestations ... photophobia • GI - Inflammatory ... endoscopy (Not Inflammatory ... Bladder and bowel incontinence ... diagnosis #signs #symptoms
Benign Prostatic Hyperplasia: Pathogenesis and Clinical Findings Hormonal alterations (result of aging process) ->
FGF-related proteins) Inflammation ... granulocytes) -> Prostate Inflammation ... activation of inflammatory ... Urgency, nocturia, incontinence ... bladder stones #BPH
Rheumatoid arthritis (RA): Pathogenesis and Joint diseases features • RA affects 1% of population, women >
Extra-articular manifestations ... • Rate of inflammatory ... etc • Systemic inflammation ... pathophysiology #signs #symptoms
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