The Calgary Guide to Understanding Disease @TheCalgaryGuide
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pathophysiology diagnosis signs symptoms complications adhesivecapsulitis ankylosingspondylitis cascade comparison degenerative extraarticular frozenshoulder jointdisease jointpain lupus mucocutaneous ra rheumatoidarthritis sle stages
Inflammatory Cascade: Pathogenesis and Clinical Findings Continued Innate Immunity • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
Inflammatory Cascade ... destruction), promote inflammation ... cell activity #Inflammatory ... #Cascade #Inflammation ... pathophysiology #immunology
Distinguishing between Inflammatory and Degenerative joint disease Inflammatory Joint Disease • Swelling stimulates joint nociceptors -> Pain
joint disease Inflammatory ... Swollen Joints • Inflammation ... Extra-articular manifestations ... mild synovial inflammation ... Comparison #Versus #MSK
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Mucocutaneous Manifestations ... cytokines -> localized inflammatory ... scaling that extend inflammation ... -> Incr local inflammation ... Mucocutaneous #Manifestations
Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings • Primary (Idiopathic): Unknown etiology, but associated
shoulder joint inflammation ... as post-inflammatory ... shoulder joint inflammation ... stop, but post-inflammatory ... stages #staging #msk
Rheumatoid arthritis (RA): Pathogenesis and Joint diseases features • RA affects 1% of population, women >
Extra-articular manifestations ... • Rate of inflammatory ... etc • Systemic inflammation
Ankylosing Spondylitis: Extra-articular Manifestations • Ocular - Inflammation of the iris, the anterior part of the
Extra-articular Manifestations ... • Ocular - Inflammation ... photophobia • GI - Inflammatory ... endoscopy (Not Inflammatory ... Extraarticular #Manifestations
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