The Calgary Guide to Understanding Disease @TheCalgaryGuide
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pathophysiology diagnosis signs complications manifestations ophthalmology adhesivecapsulitis ankylosingspondylitis benign bph cascade caudaequina causes centralretinalartery childhood comparison crao extraarticular frozenshoulder gait
Inflammatory Cascade: Pathogenesis and Clinical Findings Continued Innate Immunity • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
Inflammatory Cascade ... destruction), promote inflammation ... cell activity #Inflammatory ... #Cascade #Inflammation ... pathophysiology #immunology
Distinguishing between Inflammatory and Degenerative joint disease Inflammatory Joint Disease • Swelling stimulates joint nociceptors -> Pain
and Degenerative ... Swollen Joints • Inflammation ... mild synovial inflammation ... #Degenerative # ... Comparison #Versus #MSK
Cauda Equina Syndrome Causes: • Large lumbar degenerative disc herniation (central) • Severe lumbar spondylosis • Neoplasm
• Large lumbar degenerative ... spine Signs / Symptoms ... CaudaEquina #Syndrome #MSK ... pathophysiology #diagnosis #symptoms
Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings • Primary (Idiopathic): Unknown etiology, but associated
shoulder joint inflammation ... as post-inflammatory ... shoulder joint inflammation ... pathophysiology #diagnosis #symptoms ... stages #staging #msk
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
cytokines -> localized inflammatory ... scaling that extend inflammation ... -> Incr local inflammation ... follicles due to inflammation ... diagnosis #signs #symptoms
Mastoiditis: Pathogenesis and clinical findings Acute or Chronic Otitis Media -> Stage 1: Hyperemeia of the mastoid
mastoid air cells (inflammation ... mucosa leads to inflammation ... mastoid air cells (inflammation ... : Extension of inflammatory ... pathophysiology #signs #symptoms
Trendelenburg Gait: Pathogenesis and clinical findings Skeletal Pathology of the Hip • Arthritis • Congenital hip dysplasia
around the hip • Degeneration ... pathophysiology #causes #symptoms ... signs #diagnosis #msk
Childhood Immunization Schedule: Why we immunize • Diphtheria Toxin -> URT inflammation causes pseudomembrane with hardened
Diphtheria Toxin -> URT inflammation ... hemorrhagic rash; symptoms ... Metabolites -> Inflammation ... hepatocellular necrosis & degeneration ... non-specific viral symptoms
Central Retinal Artery Occlusion: Pathogenesis and clinical findings • Inflammatory Disease: (i.e. GCA, SLE, GPA) ->
clinical findings • Inflammatory ... viscosity and inflammation ... diagnosis #signs #symptoms
Rheumatoid arthritis (RA): Pathogenesis and Joint diseases features • RA affects 1% of population, women >
• Rate of inflammatory ... etc • Systemic inflammation ... pathophysiology #signs #symptoms
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