The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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pathophysiology signs complications ankylosingspondylitis centralretinalartery comparison degenerative extraarticular jointdisease jointpain msk mucocutaneous occlusion ophthalmology ra rheumatoidarthritis sle versus
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Manifestations ... cytokines -> localized inflammatory ... Mucocutaneous #Manifestations ... pathophysiology #diagnosis ... #signs #symptoms
Central Retinal Artery Occlusion: Pathogenesis and clinical findings • Inflammatory Disease: (i.e. GCA, SLE, GPA) ->
clinical findings • Inflammatory ... viscosity and inflammation ... due to upstream CRAO ... ophthalmology #diagnosis ... #signs #symptoms
Distinguishing between Inflammatory and Degenerative joint disease Inflammatory Joint Disease • Swelling stimulates joint nociceptors -> Pain
Swollen Joints • Inflammation ... Rheumatoid arthritis, Lupus ... Extra-articular manifestations ... mild synovial inflammation ... JointDisease #JointPain #Diagnosis
Rheumatoid arthritis (RA): Pathogenesis and Joint diseases features • RA affects 1% of population, women >
Extra-articular manifestations ... • Rate of inflammatory ... etc • Systemic inflammation ... pathophysiology #signs #symptoms ... #diagnosis
Ankylosing Spondylitis: Extra-articular Manifestations • Ocular - Inflammation of the iris, the anterior part of the
Extra-articular Manifestations ... photophobia • GI - Inflammatory ... endoscopy (Not Inflammatory ... pathophysiology #diagnosis ... #signs #symptoms
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