The Calgary Guide to Understanding Disease @TheCalgaryGuide
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hypersensitivityreaction anaphylaxis c5c9deficiency cascade diagnosis gout humoral hyperuricemia immunity inflammation inflammatory management oncogenesis oncology signs symptoms tophaceous tophi treatments type1
Type I Hypersensitivity: Pathogenesis and clinical findings Definition: Production of lgE Antibodies that bind to harmless allergens
leading to an allergic ... Sensitization" to Allergen ... Initial exposure to allergen ... cells recruited Complications ... #Immunology #pathophysiology
Retroviral Infections: Mechanisms of Oncogenesis Note: A retrovirus is an RNA virus that uses reverse transcriptase to
Retroviral Infections ... Oncogenesis Note: A retrovirus ... /leukemia) #Retroviral ... #oncogenesis #pathophysiology ... #immunology #oncology
Type IV Hypersensitivity: Pathogenesis and clinical findings Definition: Unique because it is entirely T-Cell mediated; exposure to
mediated; exposure to allergen ... development of allergen-specific ... Allergic reaction ... Initial exposure to allergen ... #Immunology #pathophysiology
Inflammatory Cascade: Pathogenesis and Clinical Findings Continued Innate Immunity • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
dead tissue • Complement ... activation of complement ... #Inflammation #pathophysiology ... #immunology
Type III Hypersensitivity: Pathogenesis and clinical findings Definition: Small antigen-antibody complexes (produced from normal immune response to
HypersensitivityReaction #Allergy ... #Immunology #pathophysiology
Anaphylaxis: Signs and Symptoms Anaphylaxis: when any egg of three conditions is met: 1. Acute onset of skin/mucosal
exposure to a likely allergen ... exposure to known allergen ... Signs / Symptoms / Complications ... #Anaphylaxis #pathophysiology ... #immunology #diagnosis
Type II Hypersensitivity: Pathogenesis and clinical findings Definition: When antigens bind to the body's cell surfaces, forming
activates the complement ... HypersensitivityReaction #Allergy ... #Immunology #pathophysiology
C5-C9 Deficiency - Pathogenesis and Clinical Findings Note: • Risk of invasive meningococcal disease is 1000-10000x higher
is rare Normal complement ... response: The complement ... activation -> Complement ... #pathophysiology ... #immunology
Humoral Immunity - Pathogenesis and Clinical Findings Antigens (Ag) are produced from pathogens (bacteria, viruses, fungi, parasites)
activation • Complement ... tagged with C3 complement ... - Activate Complement ... Humoral #Immunity #pathophysiology ... #immunology
Anaphylaxis: Treatments (Acute) Additional Info: • IV steroids may be considered for prevention of late phase reactions.
provided, as well as allergy ... Treatments #Management #pathophysiology ... #immunology
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