The Calgary Guide to Understanding Disease @TheCalgaryGuide
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hypersensitivityreaction anaphylaxis c5c9deficiency diagnosis gout hyperuricemia inflammation inflammatory signs symptoms tophaceous tophi type1 type2 typei
Inflammatory Cascade: Pathogenesis and Clinical Findings Continued Innate Immunity • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
Inflammatory Cascade ... dead tissue • Complement ... #Inflammatory #Cascade ... #Inflammation #pathophysiology ... #immunology
Type I Hypersensitivity: Pathogenesis and clinical findings Definition: Production of lgE Antibodies that bind to harmless allergens
leading to an allergic ... Sensitization" to Allergen ... Initial exposure to allergen ... cells recruited Complications ... #Immunology #pathophysiology
Type II Hypersensitivity: Pathogenesis and clinical findings Definition: When antigens bind to the body's cell surfaces, forming
activates the complement ... cascade, which ... HypersensitivityReaction #Allergy ... #Immunology #pathophysiology
C5-C9 Deficiency - Pathogenesis and Clinical Findings Note: • Risk of invasive meningococcal disease is 1000-10000x higher
is rare Normal complement ... response: The complement ... cascade -> MAC ... #pathophysiology ... #immunology
Anaphylaxis: Signs and Symptoms Anaphylaxis: when any egg of three conditions is met: 1. Acute onset of skin/mucosal
exposure to a likely allergen ... exposure to known allergen ... Signs / Symptoms / Complications ... #Anaphylaxis #pathophysiology ... #immunology #diagnosis
Gout: Pathogenesis and Clinical Findings - Conditions of rapid cell turnover: hemolysis, psoriasis, lymphoproliferative disorders -
Activation of complement ... cascade results ... Hyperuricemia #Pathophysiology ... #Complications
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