The Calgary Guide to Understanding Disease @TheCalgaryGuide
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agammaglobulinemia allergy c5c9deficiency cascade complications diagnosis differential hypersensitivityreaction hyperuricemia immunity inflammation inflammatory lfcn meralgiaparesthetica msk oncogenesis oncology signs symptoms tophaceous
Inflammatory Cascade: Pathogenesis and Clinical Findings Continued Innate Immunity • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
dead tissue • Complement ... Recruitment • Humoral ... activation of complement ... #Inflammation #pathophysiology ... #immunology
Retroviral Infections: Mechanisms of Oncogenesis Note: A retrovirus is an RNA virus that uses reverse transcriptase to
Retroviral Infections ... Oncogenesis Note: A retrovirus ... /leukemia) #Retroviral ... #oncogenesis #pathophysiology ... #immunology #oncology
Humoral Immunity - Pathogenesis and Clinical Findings Antigens (Ag) are produced from pathogens (bacteria, viruses, fungi, parasites)
Humoral Immunity ... activation • Complement ... repeat exposure #Humoral ... #Immunity #pathophysiology ... #immunology
C5-C9 Deficiency - Pathogenesis and Clinical Findings Note: • Risk of invasive meningococcal disease is 1000-10000x higher
is rare Normal complement ... response: The complement ... proteins leak out ... #pathophysiology ... #immunology
Gout: Pathogenesis and Clinical Findings - Conditions of rapid cell turnover: hemolysis, psoriasis, lymphoproliferative disorders -
Gout: Pathogenesis ... Activation of complement ... Chronic tophaceous gout ... Hyperuricemia #Pathophysiology ... Complications #Gout
Type II Hypersensitivity: Pathogenesis and clinical findings Definition: When antigens bind to the body's cell surfaces, forming
activates the complement ... HypersensitivityReaction #Allergy #Immunology ... #pathophysiology
X-Linked Agammaglobulinemia: Pathogenesis and clinical findings The epidemiology of this disease is 1/340,000 births and roughly double
deficiency in adaptive humoral ... Agammaglobulinemia #XLinked #pathophysiology ... #immunology
Meralgia paresthetica: Pathogenesis and Clinical Findings Compression/injury of Lateral Femoral Cutaneous Nerve (LFCN) -> Meralgia paresthetica •
injury of Lateral Femoral ... be made, rule out ... MeralgiaParesthetica #MSK #pathophysiology
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