The Calgary Guide to Understanding Disease @TheCalgaryGuide
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allergy hypersensitivityreaction c5c9deficiency cascade complications humoral hyperuricemia immunity inflammatory oncogenesis oncology tophaceous tophi type2 type4 typeiv
Inflammatory Cascade: Pathogenesis and Clinical Findings Continued Innate Immunity • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
dead tissue • Complement ... destruction), promote inflammation ... activation of complement ... #pathophysiology ... #immunology
Retroviral Infections: Mechanisms of Oncogenesis Note: A retrovirus is an RNA virus that uses reverse transcriptase to
Retroviral Infections ... Oncogenesis Note: A retrovirus ... /leukemia) #Retroviral ... #oncogenesis #pathophysiology ... #immunology #oncology
C5-C9 Deficiency - Pathogenesis and Clinical Findings Note: • Risk of invasive meningococcal disease is 1000-10000x higher
response: The complement ... proteins leak out ... • Inflammation ... #pathophysiology ... #immunology
Humoral Immunity - Pathogenesis and Clinical Findings Antigens (Ag) are produced from pathogens (bacteria, viruses, fungi, parasites)
activation • Complement ... tagged with C3 complement ... - Activate Complement ... Humoral #Immunity #pathophysiology ... #immunology
Gout: Pathogenesis and Clinical Findings - Conditions of rapid cell turnover: hemolysis, psoriasis, lymphoproliferative disorders -
Gout: Pathogenesis ... Activation of complement ... Chronic tophaceous gout ... Hyperuricemia #Pathophysiology ... Complications #Gout
Type IV Hypersensitivity: Pathogenesis and clinical findings Definition: Unique because it is entirely T-Cell mediated; exposure to
cells or CTLs -> Inflammation ... HypersensitivityReaction #Allergy #Immunology ... #pathophysiology
Type II Hypersensitivity: Pathogenesis and clinical findings Definition: When antigens bind to the body's cell surfaces, forming
activates the complement ... HypersensitivityReaction #Allergy #Immunology ... #pathophysiology
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