The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Pituitary Mass Effects - Pathogenesis and Clinical Findings
 • Pituitary turnors are almost always a benign
following order; GH ... A good mnemonic ... Signs / Symptoms ... #SideEffects #endocrinology ... #mnemonic #GLFTAP
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Growth Hormone (GH ... lipolysis Signs/Symptoms ... : • GH deficiency ... abn lipid • GH ... #FeedbackLoop #endocrinology
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
time of onset of GH ... GH excess prior ... GH excess after ... diagnosis #signs #symptoms ... #endocrinology
Graves’ Disease: Pathogenesis and Clinical Findings
B & T lymphocyte mediated autoimmunity attack TSH receptor -> Continuous
etiology Signs/Symptoms ... pathophysiology #endocin #endocrinology ... #symptoms #signs
Borderline Personality Disorder: Pathogenesis and Clinical Findings
Behavioral Traits:
 • Unstable Relationships - Alternating extremes of idealization
severe dissociative symptoms ... experienced BPD Mnemonic ... the above with symptoms ... Criteria #Signs #Symptoms ... #Mnemonic #AMSUICIDE
Primary Hyperthyroidism - Pathogenesis and Clinical Findings

Note: Although rare, gestational diseases can lead to thyrotoxicosis due
Signs/Symptoms: ... Hyperthyroidism #endocrinology
Schizotypal Personality Disorder (SPD): Pathogenesis and clinical findings
Cognitive-Perceptual
 • Magical thinking - Belief in paranormal or
familiarity SPD Mnemonic ... Criteria #Signs #Symptoms ... #Mnemonic #MEPECULIAR
Dependent Personality Disorder (DPD): Pathogenesis and Clinical Findings
 • Difficulties with Activities - Initiation Of projects
themselves DPD Mnemonic ... Criteria #Signs #Symptoms ... #Mnemonic #RELIANCE
Mental Status Exam (MSE)
Note: The MSE is a "snapshot" of a patient at a specific time.
You
You can use the mnemonic ... of illness, the symptoms ... diagnosis #evaluation #mnemonic
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings
Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
Signs/Symptoms/Complications ... pathophysiology #genetics #endocrinology