The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Subtrochanteric Femur Fracture: Pathogenesis and clinical findings
 • Subtrochanteric region spans 5 cm distally from the
Subtrochanteric Femur Fracture ... in elderly Causes ... #msk #orthopedics ... #diagnosis #differential ... #causes #pathophysiology
Anticonvulsants as Mood Stabilizers: Mechanism and Side-effect
Examples: Valproate, Carbamazepine, Lamotrigine
 • Mild anticholinergic effect -> Drowsiness
constipation • Allergic ... Stevens-Johnson Syndrome ... relapse of bipolar disorder ... Systemic effect -> Nausea
Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings

 • Primary (Idiopathic): Unknown etiology, but associated
with autoimmune disorders ... , humeral head fracture ... a stroke that caused ... stages #staging #msk
Acquired Disorders of Reduced Bone Strength: Pathogenesis
 • Hyperparathyroidism
 • Vitamin D deficiency
 • Malabsorption syndromes
Acquired Disorders ... Malabsorption syndromes ... Diabetes • Other causes ... Sedondary #Acquired #Disorders ... pathophysiology #differential
Fracture Healing (and disruptors of this process)
Inflammatory Stage (0-7d)
 • Fracture disrupts local blood vessels ->
Fracture Healing ... Stage (0-7d) • Fracture ... Metabolic / Endocrine disorders ... Fluoroquinolones - Causes ... #Orthopedics #msk
Paget’s Disease: Complications
Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation

MSK
Abnormal Osteoclasts cause ... bone formation MSK ... -> Pathologic fractures ... Skull expansion causes ... Nerve Palsies • Disordered