The Calgary Guide to Understanding Disease @TheCalgaryGuide
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pathophysiology diagnosis signs symptoms stages acquired adhesivecapsulitis anticonvulsants bonestrength caudaequina complications disruptors fracture frozenshoulder mechanism moodstabilizers orthopedics osteoporosis pagetsdisease pharmacology
Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings • Primary (Idiopathic): Unknown etiology, but associated
with autoimmune disorders ... a stroke that caused ... post-inflammatory healing ... signs #stages #staging ... #msk
Anticonvulsants as Mood Stabilizers: Mechanism and Side-effect Examples: Valproate, Carbamazepine, Lamotrigine • Mild anticholinergic effect -> Drowsiness
constipation • Allergic ... Stevens-Johnson Syndrome ... relapse of bipolar disorder ... Systemic effect -> Nausea
Cauda Equina Syndrome Causes: • Large lumbar degenerative disc herniation (central) • Severe lumbar spondylosis • Neoplasm
Cauda Equina Syndrome ... Causes: • Large ... pain (shooting, stabbing ... #CaudaEquina #Syndrome ... #MSK #pathophysiology
Fracture Healing (and disruptors of this process) Inflammatory Stage (0-7d) • Fracture disrupts local blood vessels ->
Fracture Healing ... Metabolic / Endocrine disorders ... Fluoroquinolones - Causes ... #Orthopedics #msk ... #Staging #pathophysiology
Acquired Disorders of Reduced Bone Strength: Pathogenesis • Hyperparathyroidism • Vitamin D deficiency • Malabsorption syndromes
Acquired Disorders ... Malabsorption syndromes ... Diabetes • Other causes ... Sedondary #Acquired #Disorders ... pathophysiology #differential
Paget’s Disease: Complications Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation MSK
Abnormal Osteoclasts cause ... bone formation MSK ... Skull expansion causes ... Nerve Palsies • Disordered ... -> Conductive hearing
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