The Calgary Guide to Understanding Disease @TheCalgaryGuide
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pathophysiology diagnosis signs symptoms pharmacology psychiatry sideeffects inhibitors orthopedics acquired anticonvulsants bonestrength caudaequina cecs chronicexertional compartmentsyndrome disorders disruptors femur fracture
Type IV Hypersensitivity: Pathogenesis and clinical findings Definition: Unique because it is entirely T-Cell mediated; exposure to
mediated; exposure to allergen ... causes development ... of allergen-specific ... Allergic reaction ... Stevens-Johnson Syndrome
Anticonvulsants as Mood Stabilizers: Mechanism and Side-effect Examples: Valproate, Carbamazepine, Lamotrigine • Mild anticholinergic effect -> Drowsiness
Mood Stabilizers: Mechanism ... constipation • Allergic ... Stevens-Johnson Syndrome ... Systemic effect -> Nausea ... MoodStabilizers #Mechanism
Selective Serotonin Reuptake Inhibitors: Mechanisms and Side Effects • Serotonin Syndrome: - Autonomic Hyperactivity:
Reuptake Inhibitors: Mechanisms ... • Serotonin Syndrome ... SSRI Withdrawal Syndrome ... Dizziness - Nausea
Serotonin-Norepinephrine Reuptake Inhibitors(SNRIs): Mechanisms and Side Effects Withdrawal: Dizziness, Diarrhea, Insomnia, Nausea, Vomiting Serotonin Syndrome - Potentially Life
Inhibitors(SNRIs): Mechanisms ... Diarrhea, Insomnia, Nausea ... Vomiting Serotonin Syndrome ... gain Incr NE: Nausea
Cauda Equina Syndrome Causes: • Large lumbar degenerative disc herniation (central) • Severe lumbar spondylosis • Neoplasm
Cauda Equina Syndrome ... Causes: • Large ... #CaudaEquina #Syndrome ... #MSK #pathophysiology
Subtrochanteric Femur Fracture: Pathogenesis and clinical findings • Subtrochanteric region spans 5 cm distally from the
fractures in elderly Causes ... Femur #Fractures #msk ... orthopedics #diagnosis #differential ... #causes #pathophysiology
Shoulder Impingement Syndrome (SIS): Signs and Symptoms Repetitive Overhead Activity, Scapular Dyskinesis -> Scapulohumeral mechanics become altered
Shoulder Impingement Syndrome ... Scapulohumeral mechanics ... Shoulder Impingement Syndrome ... #Impingement #Syndrome ... signs #symptoms #msk
Chronic Exertional Compartment Syndrome (CECS) • Diagnosis Of CECS requires patient to undergo the same exertional
Exertional Compartment Syndrome ... activity that causes ... signs #symptoms #msk
Acquired Disorders of Reduced Bone Strength: Pathogenesis • Hyperparathyroidism • Vitamin D deficiency • Malabsorption syndromes
Malabsorption syndromes ... Diabetes • Other causes ... pathophysiology #differential
Fracture Healing (and disruptors of this process) Inflammatory Stage (0-7d) • Fracture disrupts local blood vessels ->
healing time, mechanisms ... Fluoroquinolones - Causes ... #Orthopedics #msk
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