The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Hypersensitivity: Summary
Type I Hypersensitivity:
 • Immunological Mediator: lgE
 • Immunological Target: Allergen Molecules
 • Ex: Antibiotic
Hypersensitivity ... Summary Type I Hypersensitivity ... Disease Type III Hypersensitivity ... poison ivy) #Hypersensitivity ... Reactions #Types #Classification
Open Fractures: Mechanisms, Clinical Features and Complications
Gustilo-Anderson Classification:
 • Type I
   - Wound <
Gustilo-Anderson Classification ... GustiloAnderson #Classification ... Complications #MSK
Classification of Pelvic Ring Fractures: Mechanisms, Clinical Features and Complications
 • Anterior Posterior Compression (APC) -
Classification of ... PelvicRing #Fractures #Classification ... #Orthopedics #MSK
Type III Hypersensitivity: Pathogenesis and clinical findings
Definition: Small antigen-antibody complexes (produced from normal immune response to
Type III Hypersensitivity
Anaphylaxis: Pathogenesis
Anaphylaxis is a Type 1 hypersensitivity reaction
While the primary mechanism of anaphylaxis is mast cell
Anaphylaxis is a Type 1 hypersensitivity
Spondylosis - Pathogenesis and Complications

Vertebral disease that may compress the vertebral canal from all sides
Note: Do
pathophysiology #msk
Obsessive-Compulsive Disorder (OCD): Pathogenesis and clinical findings

Psychological Hypothesis
 • Cognitive behavioral model: Emotional disturbance arising from
• Serotonin: Hypersensitivity
Type IV Hypersensitivity: Pathogenesis and clinical findings
Definition: Unique because it is entirely T-Cell mediated; exposure to
Type IV Hypersensitivity
Stress Fracture: Pathogenesis and clinical findings
Abnormal biomechanics, Repetitive impact activities
=> Repetitive subthreshold mechanical loading
=> Bone strain
=>
StressFractures #msk
Myelopathy - Injury to the entire spinal cord - Signs and Symptoms
 • Ataxia (early sign)
signs #symptoms #msk