The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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pathophysiology diagnosis signs symptoms orthopedics classification allergic complications definitions grades hypersensitivity hypersensitivityreaction immunology reactions types acute anticonvulsants carpaltunnel caudaequina cecs
Type I Hypersensitivity: Pathogenesis and clinical findings Definition: Production of lgE Antibodies that bind to harmless allergens
degranulation, leading ... to an allergic ... Sensitization" to Allergen ... Initial exposure to allergen ... after clearance of allergen
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
Immunological Target: Allergen ... fever, Urticaria, Allergic ... Stevens-Johnson Syndrome ... Hypersensitivity #Allergy ... #Allergic #Reactions
Type IV Hypersensitivity: Pathogenesis and clinical findings Definition: Unique because it is entirely T-Cell mediated; exposure to
mediated; exposure to allergen ... development of allergen-specific ... Allergic reaction ... Initial exposure to allergen ... Stevens-Johnson Syndrome
Low Ankle Sprain: Pathomechanics and Clinical Findings Grading Ligament Sprains l: Minimal ligament disruption, mild swelling & tenderness,
Clinical Findings Grading ... ligament substance leading ... ligament substance leading ... LowAnkleSprain #Sports #MSK ... #orthopedics #Grading
Patellofemoral Syndrome - Pathogenesis and clinical findings • Anterior Knee Pain with possible symptoms of 'catching'
Patellofemoral Syndrome ... pain • Palpable grinding ... Patellofemoral #Syndrome ... signs #symptoms #msk
Stress Fracture: Pathogenesis and clinical findings Abnormal biomechanics, Repetitive impact activities => Repetitive subthreshold mechanical loading => Bone strain =>
subthreshold mechanical loading ... from continued loading ... StressFractures #msk
Hypersensitivity: Definitions • Type I - Production of lgE Abs that bind to harmless allergens and
degranulation, leading ... to an allergic ... antigen-surface complex, leading ... to an allergic ... immune reaction, leading
Acute Spinal Cord Injuries: Pathogenesis and clinical findings • Anterior Cord Syndrome -> Anterior spinal artery
Anterior Cord Syndrome ... • Central Cord Syndrome ... Posterior Cord Syndrome ... Brown-Sequard Syndrome ... signs #symptoms #msk
Carpal Tunnel Syndrome: Pathogenesis and clinical findings • Dysthesias - Tingling, burning, or painful sensation at
Carpal Tunnel Syndrome ... #CarpalTunnel #Syndrome ... pathophysiology #msk
Cubital Tunnel Syndrome: Pathogenesis and clinical findings • Paresthesia of 5th and medial half of 4th
Cubital Tunnel Syndrome ... CubitalTunnel #Syndrome ... signs #symptoms #msk
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