The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Low Ankle Sprain: Pathomechanics and Clinical Findings

Grading Ligament Sprains
l: Minimal ligament disruption, mild swelling & tenderness,
Clinical Findings Grading ... ligament substance leading ... ligament substance leading ... LowAnkleSprain #Sports #MSK ... #orthopedics #Grading
Patellofemoral Syndrome - Pathogenesis and clinical findings
 • Anterior Knee Pain with possible symptoms of 'catching'
Patellofemoral Syndrome ... pain • Palpable grinding ... Patellofemoral #Syndrome ... signs #symptoms #msk
Stress Fracture: Pathogenesis and clinical findings
Abnormal biomechanics, Repetitive impact activities
=> Repetitive subthreshold mechanical loading
=> Bone strain
=>
subthreshold mechanical loading ... from continued loading ... StressFractures #msk
Diabetic Retinopathy: Pathogenesis and clinical findings

Mild Non-proliferative DR
 • Outpouchings of the weakened capillary walls or
Diabetic Retinopathy ... ischemia -> Venous beading ... Neovascularization #Diabetic ... #Retinopathy #Diabetes
Acute Spinal Cord Injuries: Pathogenesis and clinical findings
 • Anterior Cord Syndrome -> Anterior spinal artery
Anterior Cord Syndrome ... • Central Cord Syndrome ... Posterior Cord Syndrome ... Brown-Sequard Syndrome ... signs #symptoms #msk
Diabetic Foot: Pathogenesis and clinical findings
 • Polyol Pathway - Excess glucose enters Polyol pathway ->
Diabetic Foot: Pathogenesis ... neuropathy => Diabetic ... a person with diabetes ... in inopportune loading ... complications #Diabetes
Prader-Willi Syndrome: Pathogenesis and clinical findings
 • Maternal uniparental disomy: inheriting 2 copies of maternal chromosome
Prader-Willi Syndrome ... =>Prader-Willi Syndrome ... Obesity -> Type 2 diabetes ... #PraderWilli #Syndrome
Carpal Tunnel Syndrome: Pathogenesis and clinical findings
 • Dysthesias - Tingling, burning, or painful sensation at
Carpal Tunnel Syndrome ... #CarpalTunnel #Syndrome ... pathophysiology #msk
Cubital Tunnel Syndrome: Pathogenesis and clinical findings

 • Paresthesia of 5th and medial half of 4th
Cubital Tunnel Syndrome ... CubitalTunnel #Syndrome ... signs #symptoms #msk
Disc Herniations - Pathogenesis and Complications
• 90% of Lumbar disc herniations happen at L4/5 and L5/S1
•
-> Mechanical loading ... complications #msk