The Calgary Guide to Understanding Disease @TheCalgaryGuide
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diagnosis signs symptoms fractures hypersensitivityreaction anaphylaxis classification grades grading achilles acute anterior boutonniere caudaequina causes deformity differential discherniations dislocation disruptors
Type I Hypersensitivity: Pathogenesis and clinical findings Definition: Production of lgE Antibodies that bind to harmless allergens
leading to an allergic ... Sensitization" to Allergen ... Initial exposure to allergen ... cells recruited Complications ... #Immunology #pathophysiology
Type IV Hypersensitivity: Pathogenesis and clinical findings Definition: Unique because it is entirely T-Cell mediated; exposure to
mediated; exposure to allergen ... development of allergen-specific ... Allergic reaction ... Initial exposure to allergen ... #Immunology #pathophysiology
Type III Hypersensitivity: Pathogenesis and clinical findings Definition: Small antigen-antibody complexes (produced from normal immune response to
HypersensitivityReaction #Allergy ... #Immunology #pathophysiology
Anaphylaxis: Signs and Symptoms Anaphylaxis: when any egg of three conditions is met: 1. Acute onset of skin/mucosal
exposure to a likely allergen ... exposure to known allergen ... Signs / Symptoms / Complications ... #Anaphylaxis #pathophysiology ... #immunology #diagnosis
Spondylosis - Pathogenesis and Complications Vertebral disease that may compress the vertebral canal from all sides Note: Do
Pathogenesis and Complications ... #Spondylosis #pathophysiology ... #msk #complications
Open Fractures: Mechanisms, Clinical Features and Complications Gustilo-Anderson Classification: • Type I - Wound <
Clinical Features and Complications ... Fractures #Diagnosis #Complications ... #MSK #Orthopedics
Stress Fracture: Pathogenesis and clinical findings Abnormal biomechanics, Repetitive impact activities => Repetitive subthreshold mechanical loading => Bone strain =>
StressFractures #msk ... #orthopedics #pathophysiology
Femoral Head Fracture: Pathogenesis and clinical findings • Posterior hip dislocation -> Impaction force from femoral
Signs/Symptoms/Complications ... FemoralHead #Fractures #msk ... #diagnosis #pathophysiology ... signs #symptoms #orthopedics
Achilles Tendon Rupture - Pathogenesis and clinical findings • The Achilles tendon is 15cm long in
Signs/Symptoms/Complications ... signs #symptoms #pathophysiology ... #msk #orthopedics
Disc Herniations - Pathogenesis and Complications • 90% of Lumbar disc herniations happen at L4/5 and L5/S1 •
Pathogenesis and Complications ... DiscHerniations #complications ... #msk #pathophysiology
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