The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Myopathy (Also caused ... Erythematosus #SLE #MSK ... Musculoskeletal #Complications ... #pathophysiology ... signs #symptoms #diagnosis
Lupus (SLE): Mucocutaneous Manifestations

 • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
cytokines -> localized inflammatory ... hair follicles -> causes ... Manifestations #pathophysiology ... #diagnosis #signs ... #symptoms #complications
Distinguishing between Inflammatory and Degenerative joint disease
Inflammatory Joint Disease
 • Swelling stimulates joint nociceptors -> Pain
Rheumatoid arthritis, Lupus ... > Stiffness is short-lived ... Comparison #Versus #MSK ... JointDisease #JointPain #Diagnosis ... #pathophysiology
Bulimia Nervosa: Signs and Symptoms
Associated Psychological / Behavioural Features
 • Feelings of shame, guilt and embarrassment
Symptoms related to complications ... , scars, calluses ... BulimiaNervosa #pathophysiology ... #diagnosis #signs ... #symptoms #psychiatry