The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Myopathy (Also caused ... Erythematosus #SLE #MSK ... Musculoskeletal #Complications ... pathophysiology #signs #symptoms
Childhood Immunization Schedule: Why we immunize
 • Diphtheria Toxin -> URT inflammation causes pseudomembrane with hardened
Tetanus Toxin -> Spores ... cause quadriplegia ... hemorrhagic rash; symptoms ... lymph -> Koplik's spots ... non-specific viral symptoms
Cauda Equina Syndrome
Causes:
 • Large lumbar degenerative disc herniation (central)
 • Severe lumbar spondylosis
 • Neoplasm
Equina Syndrome Causes ... spine Signs / Symptoms ... / Complications ... CaudaEquina #Syndrome #MSK ... pathophysiology #diagnosis #symptoms
Acquired Immunodeficiency Syndrome (AIDS): Summary of Causes and Ocular Manifestations
 • Molluscum lesions
 • Eyelid Kaposi
AIDS): Summary of Causes ... • Cotton wool spots ... #AIDS #Ocular #Complications
Chronic Hypertensive Retinopathy: Pathogenesis and clinical findings

Ophthalmic Artery Hypertension
Stage 1: Mild/vasoconstrictive
 • Acute and chronic vasospasm
hyalinization causes ... -> Cotton-wool Spots ... -> Elschnig's Spots ... diagnosis #signs #symptoms ... #complications
Femoral Head Fracture: Pathogenesis and clinical findings
 • Posterior hip dislocation -> Impaction force from femoral
lateral hip Signs/Symptoms ... /Complications: ... FemoralHead #Fractures #msk ... pathophysiology #signs #symptoms
Alzheimer’s Disease: Pathogenesis and Clinical Findings
Risk factor for Late Onset Alzheimer's (99% of cases):
 - Increasing
Alzheimer's (99% of cases ... Alzheimer's (1% of cases ... chromosome 21) Signs / Symptoms ... / Complications ... diagnosis #signs #symptoms
Achilles Tendon Rupture - Pathogenesis and clinical findings
 • The Achilles tendon is 15cm long in
etiology Signs/Symptoms ... /Complications: ... diagnosis #signs #symptoms ... pathophysiology #msk
Prader-Willi Syndrome: Pathogenesis and clinical findings
 • Maternal uniparental disomy: inheriting 2 copies of maternal chromosome
Syndrome Signs/Symptoms ... /Complications: ... fractures • Short
Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings
 • Note: in DKA, body K+ is lost
out of cells may cause ... anion gap until it closes ... Signs/Symptoms/Complications ... Abdominal pain, nausea