The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Type III Hypersensitivity: Pathogenesis and clinical findings
Definition: Small antigen-antibody complexes (produced from normal immune response to
self-antigens are the cause ... antigens are the cause ... HypersensitivityReaction #Allergy #Immunology ... #pathophysiology
Type IV Hypersensitivity: Pathogenesis and clinical findings
Definition: Unique because it is entirely T-Cell mediated; exposure to
exposure to allergen causes ... HypersensitivityReaction #Allergy #Immunology ... #pathophysiology
Subtrochanteric Femur Fracture: Pathogenesis and clinical findings
 • Subtrochanteric region spans 5 cm distally from the
fractures in elderly Causes ... Fractures #msk #orthopedics ... #differential #causes ... #pathophysiology
Chronic Hypertensive Retinopathy: Pathogenesis and clinical findings

Ophthalmic Artery Hypertension
Stage 1: Mild/vasoconstrictive
 • Acute and chronic vasospasm
hyalinization causes ... BRB breakdown causes ... disc arterioles causes ... #Retinopathy #pathophysiology ... #ophthalmology
Diabetic Retinopathy: Pathogenesis and clinical findings

Mild Non-proliferative DR
 • Outpouchings of the weakened capillary walls or
retinal ischemia causes ... Retinopathy #Diabetes #ophthalmology ... complications #pathophysiology
X-Linked Agammaglobulinemia: Pathogenesis and clinical findings
The epidemiology of this disease is 1/340,000 births and roughly double
to produce all classes ... Agammaglobulinemia #XLinked #pathophysiology ... #immunology
Central Retinal Artery Occlusion: Pathogenesis and clinical findings
 • Inflammatory Disease: (i.e. GCA, SLE, GPA) ->
retinal edema caused ... Occlusion #CRAO #pathophysiology ... #ophthalmology
Acute Closed Angle Glaucoma: Pathogenesis and Clinical Findings
OPHTHALMIC EMERGENCY: Early detection is essential, but most patients
• Significant cause ... most frequent cause ... ClosedAngle #Glaucoma #pathophysiology ... #ophthalmology
Aqueous Humor Production and Drainage
 • Provides nutrition, removes wastes, and transports neurotransmitters to the avascular
of flow) -> AH passes ... suprachoroidal space -> Passes ... Drainage #flow #Pathophysiology ... #ophthalmology
Retroviral Infections: Mechanisms of Oncogenesis
Note: A retrovirus is an RNA virus that uses reverse transcriptase to
RNA virus that uses ... #oncogenesis #pathophysiology ... #immunology #oncology