The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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diagnosis signs complications msk sle acute avascularnecrosis centralretinalartery chronic closedangle crao erythematosus fracture glaucoma healing hypertensive manifestations mucocutaneous musculoskeletal occlusion
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... Myopathy (Also caused ... #Systemic #Lupus ... Complications #pathophysiology ... #signs #symptoms
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... Subacute cutaneous lupus ... hair follicles -> causes ... Manifestations #pathophysiology ... diagnosis #signs #symptoms
Chronic Hypertensive Retinopathy: Pathogenesis and clinical findings Ophthalmic Artery Hypertension Stage 1: Mild/vasoconstrictive • Acute and chronic vasospasm
hyalinization causes ... BRB breakdown causes ... #Retinopathy #pathophysiology ... #ophthalmology ... diagnosis #signs #symptoms
Acute Closed Angle Glaucoma: Pathogenesis and Clinical Findings OPHTHALMIC EMERGENCY: Early detection is essential, but most patients
lights are a key symptom ... • Significant cause ... most frequent cause ... ClosedAngle #Glaucoma #pathophysiology ... #ophthalmology
Fracture Healing (and disruptors of this process) Inflammatory Stage (0-7d) • Fracture disrupts local blood vessels ->
Fracture Healing (and disruptors ... ) • Fracture disrupts ... Fluoroquinolones - Causes ... Healing #Stages #Orthopedics ... #msk #Staging #pathophysiology
Central Retinal Artery Occlusion: Pathogenesis and clinical findings • Inflammatory Disease: (i.e. GCA, SLE, GPA) ->
retinal edema caused ... Occlusion #CRAO #pathophysiology ... #ophthalmology ... diagnosis #signs #symptoms
Avascular Necrosis: Pathogenesis and Clinical Findings • Physical Trauma (esp. to the scaphoid bone with damage
) • Multiple causes ... therapy - Lupus ... AvascularNecrosis #pathophysiology ... diagnosis #signs #symptoms
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